Author:Mangisa, M; Tembu, VJ; Fouché, Gerda; Nthambeleni, Rudzani; Peter, Xolani K; Langat, MKDate:May 2018The stem bark extract of Suregada zanzibariensis afforded a previously undescribed ent-abietane diterpenoid trivially named mangiolide (1) and a known jolkinolide B (2) via anticancer bioassay-guided fractionation. The CH(sub)2Cl(sub)2:MeOH ...Read more
Author:Mthunzi-Kufa, Patience; Dholakia, K; Gunn-Moore, FDate:Aug 2011Owing to their self renewal and pluripotency properties, stem cells can efficiently advance current therapies in tissue regeneration and/or engineering. Under appropriate culture conditions in vitro, pluripotent stem cells can be primed to ...Read more
Author:Njobeh, PB; Dutton, MF; Chuturgoon, AA; Koch, SH; Steenkamp, PA; Stoev, SDDate:Jun 2009A novel metabolite of P. polonicum was recently isolated from Cameroonian Zea mays by means of preparative silica gel thin layer chromatographic method. The potential cytotoxic effects of this novel compound was further tested, in vitro, ...Read more
Author:De Wet, H; Fouché, Gerda; Van Heerden, FRDate:20 Jul 2009The cytotoxicity of crude alkaloid extracts obtained from the leaves and rhizomes of all the South African members of the family Menispermaceae (seven genera and 13 species) was tested against MCF7 (breast), UACC62 (melanoma) and TK10 (renal) ...Read more
Author:Mthunzi-Kufa, Patience; Forbes, A; Hawkins, D; Abrahamse, H; Karsten, AEDate:2005A variety of strategies have been utilised for prevention and treatment of chronic wounds such as leg ulcers, diabetic foot ulcers and pressure sores1. Low Level Laser Therapy (LLLT) has been reported to be an invaluable tool in the enhancement ...Read more
Author:Pillay, P; Maharaj, VJ; Smith, PJDate:Oct 2008Based on the historical success of natural products as antimalarial drugs and the urgent need for new antimalarials, a number of South African medicinal plants have been evaluated for their antimalarial properties. This paper reviews the major ...Read more
Author:Pillay, P; Vleggaar, R; Maharaj, VJ; Smith, PJ; Lategan, CADate:May 2007Oncosiphon piluliferum (Asteraceae) is used traditionally to treat a variety of ailments, mainly fevers. This prompted the screening of this plant for antiplasmodial properties. The dichloromethane extract of the aerial parts of the plant ...Read more
Author:Adewusi, EA; Steenkamp, P; Fouché, Gerda; Steenkamp, VDate:Jun 2013Boophone disticha (Amaryllidaceae) is widely used in traditional medicine in southern Africa. Several alkaloids, volatile oils and fatty acids have been isolated from the plant. However, there has been no literature report of a triterpene ...Read more
Author:Nonjola, Patrick NT; Siegert, U; Swarts, JCDate:Feb 2015Ferrocenylamides, Fc–(CH(sub2))subn–CONH(sub2) with n = 0 (3a), 1 (3b), 2 (3c), and 3 (3d) and Fc =ferrocenyl = FeII(C(sub5)H(sub5))(C(sub5)H(sub4)), were synthesised by reacting aqueous ammonia with the appropriate acid chlorides, ...Read more