The cytotoxicity of crude alkaloid extracts obtained from the leaves and rhizomes of all the South African members of the family Menispermaceae (seven genera and 13 species) was tested against MCF7 (breast), UACC62 (melanoma) and TK10 (renal) cancer cell lines. While most of the extracts were active, Albertisia delagoensis and Antizoma angustifolia exhibited significant inhibition of cellular growth at TGI (total growth inhibition) values lower than 6.25 µg/ml.
Reference:
De Wet, H, Fouche, G and Van Heerden, FR. 2009. In vitro cytotoxicity of crude alkaloidal extracts of South African Menispermaceae against three cancer cell lines. African Journal of Biotechnology, Vol. 8(14), pp 3332-3335
De Wet, H., Fouché, G., & Van Heerden, F. (2009). In vitro cytotoxicity of crude alkaloidal extracts of South African Menispermaceae against three cancer cell lines. http://hdl.handle.net/10204/3874
De Wet, H, Gerda Fouché, and FR Van Heerden "In vitro cytotoxicity of crude alkaloidal extracts of South African Menispermaceae against three cancer cell lines." (2009) http://hdl.handle.net/10204/3874
De Wet H, Fouché G, Van Heerden F. In vitro cytotoxicity of crude alkaloidal extracts of South African Menispermaceae against three cancer cell lines. 2009; http://hdl.handle.net/10204/3874.
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