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Please use this identifier to cite or link to this item: http://hdl.handle.net/10204/1311

Title: Isolation and identification of antiplasmodial sesquiterpene lactones from Oncosiphon piluliferum
Authors: Pillay, P
Vleggaar, R
Maharaj, VJ
Smith, PJ
Lategan, CA
Keywords: Antiplasmodial
Sesquiterpene lactones
Oncosiphon piluliferum
Cytotoxicity
Issue Date: May-2007
Publisher: Elsevier Science B.V
Citation: Pillay, P et al. 2007. Isolation and identification of antiplasmodial sesquiterpene lactones from Oncosiphon piluliferum. Journal of Ethnopharmacology, Vol. 112(1), pp 71-76
Abstract: Oncosiphon piluliferum (Asteraceae) is used traditionally to treat a variety of ailments, mainly fevers. This prompted the screening of this plant for antiplasmodial properties. The dichloromethane extract of the aerial parts of the plant showed activity in vitro against the chloroquine-sensitive (IC50 2.6 μg/ml) and the chloroquine-resistant (IC50 3.1 μg/ml) strains of Plasmodium falciparum. Through conventional chromatographic techniques and bioassay-guided fractionation, sesquiterpene lactones of the germacranolide and eudesmanolide type displaying significant in vitro antiplasmodial activity (IC50 values ranging from 0.4 to 4.4 μg/ml) were isolated and identified by spectroscopic data. In addition, the cytotoxic effects of the active compounds against Chinese Hamster Ovarian (CHO) cells were evaluated and the compounds were found to be toxic to mammalian cells at similar concentrations. Structure–activity relationships were assessed.
Description: Copyright: 2007 Elsevier Science B.V
URI: http://hdl.handle.net/10204/1311
ISSN: 0378-8741
Appears in Collections:General science, engineering & technology
Bioprospecting

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