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Browsing by Subject "Aptamers"

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Aptamer and nanotechnology- based approaches for active targeted delivery of anti-tuberculosis drugs

Author: Ramalapa, B Date: Oct 2012 This presentation show how the formulation of multifunctional polymeric nanoparticles for encapsulation of ATD's with optimum physico-chemical properties has been achieved. Aptamers (against mannose receptors) can assist uptake of nanoparticles ... Read more
Aptamers: cutting edge technology to combat HIV/AIDS

Author: Khati, M Date: 27 Sep 2007 Oral presentation on cutting edge technology to combat HIV/AIDS by Makobetsa Khati at the Bio2Biz Conference Read more
Binding kinetics of aptamers to gp120 derived from HIV-1 subtype C

Author: Millroy, L ; London, G ; Veale, R ; Weinberg, M ; Khati, M Date: Feb 2011 Aptamers are artificial nucleic acid ligands that can be engineered to bind with high specificity to a macromolecule. Their binding specificity and small size allow for a range of therapeutic applications. One avenue of research is to develop ... Read more
Development of aptamer based HIV-1 entry inhibitor prophylactic drugs

Author: London, G ; Mufhandu, Hazel T ; Sok, D ; Morris, L ; Burton, DR ; Mayosi, B ; Khati, M Date: Aug 2013 AIDS remains a major public health problem globally, especially in Southern Africa where over 6.4 million people are infected by the most prevalent HIV-1 subtype C. To help stop the spread of HIV-1 subtype C, we isolated 2ʹ-F-RNA aptamers ... Read more
Diagnosis of active TB using aptamers

Author: Khati, M Date: Aug 2013 A lack of simple, rapid, accurate, and affordable point-of-care diagnostic tools tailored to detect active TB early enough for opportune intervention in high HIV and TB prevalence developing countries is one of defining public health problems ... Read more
Future of aptamers in medicine

Author: Khati, M Date: Jun 2010 Aptamers, simply described as chemical antibodies, are synthetic oligonucleotide ligands or peptides that can be isolated in vitro against diverse targets including toxins, bacterial and viral proteins, virus infected cells, cancer cells and ... Read more
Isolation and characterization of 20'-F-RNA aptamers against whole HIV-1 subtype C envelope pseudovirus

Author: London, GM ; Mayosi, BM ; Khati, M Date: Jan 2015 Aptamers, which are artificial nucleic acid ligands akin to antibodies in function, represent a new class of molecules that can prevent HIV infection. In this study, we isolated RNA aptamers against whole HV-1CAP45 enveloped pseudotyped virus, ... Read more
New diagnostic and therapeutic tools for tuberculosis using anti-ESAT-6/CFP-10 aptamers

Author: Rotherham, L ; Gresh, L ; Ngubane, N ; Nhlapo, J ; Khati, M Date: Nov 2008 The CSIR bioscientists are using aptamers to explore new strategies for diagnosis and mitigation of the virulence of TB. The scientists have expressed and purified His-tagged versions of TB secreted proteins ESAT-6 and CFP-10. These monomers ... Read more
Nucleic acid toolkit: Potential diagnosis and treatment of major infectious diseases endemic in developing countries

Author: Millroy, L ; Khati, M Date: Sep 2011 HIV/AIDS and TB are among the major infectious diseases and defining public health problems in developing countries. This book aims to give an overview of the epidemiology and also provide an understanding of the pathology of these diseases. ... Read more
An overview of the CSIR Health Research Impact Area

Author: Gardiner, D Date: Oct 2012 In this presentation the author provides an overview of health R&D within the CSIR, and how the organisation is responding to challenges faced by the health care sector. Read more
Providing an address for delivery of nanoencapsulated TB drugs

Author: Lemmer, Yolandy Date: Jun 2010 South Africa currently has the highest incidence of TB per 100 000 people in the world. In 2007 alone 112 000 people died of TB in South Africa, of which 94 000 were co-infected with HIV (1). Although TB treatments exist, poor patient treatment ... Read more
Towards HIV detection: Novel Poly(propylene imine) Dendrimer-Streptavidin platform for electrochemical DNA and gp120 aptamer biosensors

Author: John, SV ; Rotherham, LS ; Khati, M ; Mamba, BB ; Arotiba, OA Date: Jul 2014 The detection of sequence – specific DNA and HIV glycoprotein 120 (gp120) based on novel generation 4 poly(propylene imine) dendrimer/streptavidin platform is reported. The platform was prepared by the electrodeposition of the dendrimer on a ... Read more
UCLA1, a synthetic derivative of a gp120 RNA aptamer, inhibits entry of human immunodeficiency virus type 1 subtype C

Author: Mufhandu, Hazel T ; Gray, ES ; Madiga, MC ; Tumba, N ; Alexandre, Kabamba B ; Khoza, T ; Wibmer, CK ; Moore, PL ; Morris, L ; Khati, M Date: May 2012 Entry of human immunodeficiency virus type 1 (HIV-1) into cells is mediated by the virion surface envelope (Env) glycoproteins, making it a desirable target for antiretroviral entry inhibitors. We previously isolated a family of gp120 binding ... Read more

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Browsing by Subject "Aptamers"

Browsing by Subject "Aptamers"

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