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Please use this identifier to cite or link to this item: http://hdl.handle.net/10204/2700

Title: New diagnostic and therapeutic tools for tuberculosis using anti-ESAT-6/CFP-10 aptamers
Authors: Rotherham, L
Gresh, L
Ngubane, N
Nhlapo, J
Khati, M
Keywords: Tuberculosis
Aptamers
Issue Date: Nov-2008
Publisher: CSIR
Citation: Rotherham, L, Gresh, L, Ngubane, N et al. 2008. New diagnostic and therapeutic tools for tuberculosis using anti-ESAT-6/CFP-10 aptamers. Science real and relevant: 2nd CSIR Biennial Conference, CSIR International Convention Centre Pretoria, 17 & 18 November 2008, pp 1
Abstract: The CSIR bioscientists are using aptamers to explore new strategies for diagnosis and mitigation of the virulence of TB. The scientists have expressed and purified His-tagged versions of TB secreted proteins ESAT-6 and CFP-10. These monomers were to form the heterodimer in vitro. The scientists test the ability of the apmaters to: 1) be used as TB diagnostics tools by detecting the presence of ESAT-6 and/or CFP-10 in blood or sputum samples; 2) inhibit the virulence of M. tuberculosis in vitro and in TB mouse models.
Description: Science Real and Relevant: 2nd CSIR Biennial Conference, CSIR International Convention Centre Pretoria, 17 & 18 November 2008
URI: http://hdl.handle.net/10204/2700
Appears in Collections:CSIR Conference 2008
General science, engineering & technology

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