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Browsing by Author "Van Brummelen, AC"

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Establishing malaria parasite transfection technology in South Africa

Author: Van Brummelen, AC ; Becker, JVW ; Mancama, Dalubuhle T ; Hoppe, HC Date: Jan 2010 The most important contributing factor to the current malaria crisis is the rapid spread of parasite resistance to available anti-malarial drugs. Anti-malarial drug resistance is critical and the need for compounds with novel modes of action ... Read more
Establishing malaria parasite transfection technology in South Africa.

Author: Van Brummelen, AC ; Becker, JVW ; Mancama, Dalubuhle T ; Hoppe, H Date: Jan 2010 In order to establish malaria parasite transfection technology in South Africa, firefly luciferase and green fluorescent protein (GFP) reporter constructs were prepared. In attempt to simplify these constructs, a var intron (PFC0005w), ... Read more
In vitro anti-plasmodial activity of Dicoma anomala subsp. gerrardii (Asteraceae): identification of its main active constituent, structure-activity relationship studies and gene expression profiling

Author: Becker, JVW ; Van der Merwe, MM ; Van Brummelen, AC ; Pillay, P ; Crampton, BG ; Mmutlane, EM ; Parkinson, C ; Van Heerden, FR ; Crouch, NR ; Smith, PJ ; Mancama, Dalubuhle T ; Maharaj, VJ Date: Oct 2011 Anti-malarial drug resistance threatens to undermine efforts to eliminate this deadly disease. The resulting omnipresent requirement for drugs with novel modes of action prompted a national consortium initiative to discover new anti-plasmodial ... Read more
Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels

Author: Becker, JVW ; Mtwisha, L ; Crampton, BG ; Stoychev, Stoyan H ; Van Brummelen, AC ; Reeksting, S ; Louw, AI ; Birkholtz, LM ; Mancama, Dalubuhle T Date: Jan 2010 This study details the malaria parasite's response to PfSpdSyn inhibition on the transcriptomic, proteomic and metabolic levels. The results corroborate and significantly expand previous functional genomics studies relating to polyamine ... Read more

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Browsing by Author "Van Brummelen, AC"

Browsing by Author "Van Brummelen, AC"

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