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Please use this identifier to cite or link to this item: http://hdl.handle.net/10204/4549

Title: Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels
Authors: Becker, JVW
Mtwisha, L
Crampton, BG
Stoychev, S
Van Brummelen, AC
Reeksting, S
Louw, AI
Birkholtz, LM
Mancama, DT
Keywords: Plasmodium falciparum
Plasmodium falciparum spermidine synthase
PfSpdSyn
Antimalarial drug resistance
Malaria
Human malaria
Genomics
Issue Date: Jan-2010
Publisher: Authors
Citation: Becker, JVW, Mtwisha, L, Crampton, BG et al. 2010. Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels. BMC Genomics, Vol. 11(235), pp 1-16
Series/Report no.: Journal Article
Abstract: This study details the malaria parasite's response to PfSpdSyn inhibition on the transcriptomic, proteomic and metabolic levels. The results corroborate and significantly expand previous functional genomics studies relating to polyamine depletion in this parasite. Moreover, they confirm the role of transcriptional regulation in P. falciparum, particularly in this pathway. The findings promote this essential pathway as a target for antimalarial chemotherapeutic intervention strategies
Description: Copyright: 2010 Becker et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
URI: http://hdl.handle.net/10204/4549
ISSN: 1471-2164
Appears in Collections:Systems biology
General science, engineering & technology

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