Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels
Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels
This study details the malaria parasite's response to PfSpdSyn inhibition on the transcriptomic, proteomic and metabolic levels. The results corroborate and significantly expand previous functional genomics studies relating to polyamine depletion in this parasite. Moreover, they confirm the role of transcriptional regulation in P. falciparum, particularly in this pathway. The findings promote this essential pathway as a target for antimalarial chemotherapeutic intervention strategies
Reference:
Becker, JVW, Mtwisha, L, Crampton, BG et al. 2010. Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels. BMC Genomics, Vol. 11(235), pp 1-16
Becker, J., Mtwisha, L., Crampton, B., Stoychev, S. H., Van Brummelen, A., Reeksting, S., ... Mancama, D. T. (2010). Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels. http://hdl.handle.net/10204/4549
Becker, JVW, L Mtwisha, BG Crampton, Stoyan H Stoychev, AC Van Brummelen, S Reeksting, AI Louw, LM Birkholtz, and Dalubuhle T Mancama "Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels." (2010) http://hdl.handle.net/10204/4549
Becker J, Mtwisha L, Crampton B, Stoychev SH, Van Brummelen A, Reeksting S, et al. Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels. 2010; http://hdl.handle.net/10204/4549.
Copyright: 2010 Becker et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
ResearchSpace
