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Please use this identifier to cite or link to this item: http://hdl.handle.net/10204/5662

Title: In vitro anti-plasmodial activity of Dicoma anomala subsp. gerrardii (Asteraceae): identification of its main active constituent, structure-activity relationship studies and gene expression profiling
Authors: Becker, JVW
Van der Merwe, MM
Van Brummelen, AC
Pillay, P
Crampton, BG
Mmutlane, EM
Parkinson, C
Van Heerden, FR
Crouch, NR
Smith, PJ
Mancama, DT
Maharaj, VJ
Keywords: Malaria
Anti-malarial drug resistance
South African medicinal plants
Dicoma anomala subsp. gerrardii
Ethnomedicinal profile
Novel drugs
Anti-plasmodial agents
Issue Date: Oct-2011
Publisher: BioMed Central
Citation: Becker, JVW, Van der Merwe, MM, Van Brummelen, AC, Pillay, P, Crampton, BG, Mmutlane, EM, Parkinson, C, Van Heerden, FR, Crouch, NR, Smith, PJ, Mancama, DT and Maharaj, VJ. 2011. In vitro anti-plasmodial activity of Dicoma anomala subsp. gerrardii (Asteraceae): identification of its main active constituent, structure-activity relationship studies and gene expression profiling. Malaria Journal, vol. 10, pp 295
Series/Report no.: Workflow;8533
Abstract: Anti-malarial drug resistance threatens to undermine efforts to eliminate this deadly disease. The resulting omnipresent requirement for drugs with novel modes of action prompted a national consortium initiative to discover new anti-plasmodial agents from South African medicinal plants. One of the plants selected for investigation was Dicoma anomala subsp. gerrardii, based on its ethnomedicinal profile.
Description: Copyright: 2011 The authors.
URI: http://www.malariajournal.com/content/pdf/1475-2875-10-295.pdf
http://www.malariajournal.com/content/10/1/295
http://hdl.handle.net/10204/5662
ISSN: 1475-2875
Appears in Collections:Systems biology
General science, engineering & technology
Bioprospecting
Discovery chemistry

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