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Evaluation of the photophysicochemical properties and photodynamic therapy activity of nanoconjugates of zinc phthalocyanine linked to glutathione capped Au and Au3Ag1 nanoparticles

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dc.contributor.author Oluwole, DA
dc.contributor.author Manoto, Sello L
dc.contributor.author Malabi, Rudzani
dc.contributor.author Maphanga, Charles P
dc.contributor.author Ombinda-Lemboumba, Saturnin
dc.contributor.author Mthunzi-Kufa, Patience
dc.contributor.author Nyokong, T
dc.date.accessioned 2018-01-04T10:44:21Z
dc.date.available 2018-01-04T10:44:21Z
dc.date.issued 2018-03
dc.identifier.citation Oluwole, D.A. et al. 2018. Evaluation of the photophysicochemical properties and photodynamic therapy activity of nanoconjugates of zinc phthalocyanine linked to glutathione capped Au and Au3Ag1 nanoparticles. Dyes and Pigments, vol. 150: 139-150 en_US
dc.identifier.issn 0143-7208
dc.identifier.uri https://doi.org/10.1016/j.dyepig.2017.11.019
dc.identifier.uri https://www.sciencedirect.com/science/article/pii/S0143720817317552
dc.identifier.uri http://hdl.handle.net/10204/9912
dc.description Copyright: 2017 Elsevier. Due to copyright restrictions, the attached PDF file only contains the abstract of the full text item. For access to the full text item, please consult the publisher's website. en_US
dc.description.abstract We report on the synthesis of glutathione capped gold (AuNPs–GSH) and gold–silver (Au3Ag1NPs–GSH) nanoparticles and their covalent attachment to Zn monocarboxyphenoxy phthalocyanine (1) via amide bond formation. The photophysicochemical properties and photodynamic therapy (PDT) activity of the complex and its nanoconjugates were assessed. The conjugates afforded improved triplet and singlet oxygen quantum yield as well as PDT activity (except for 1-Au3Ag1NPs which afforded decreased activity) in comparison to complex 1. en_US
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries Worklist;19974
dc.subject Amide bond en_US
dc.subject Glutathione en_US
dc.subject Melanoma en_US
dc.subject Nanoconjugates en_US
dc.subject Singlet quantum yield en_US
dc.subject Zinc phthalocyanine en_US
dc.title Evaluation of the photophysicochemical properties and photodynamic therapy activity of nanoconjugates of zinc phthalocyanine linked to glutathione capped Au and Au3Ag1 nanoparticles en_US
dc.type Article en_US
dc.identifier.apacitation Oluwole, D., Manoto, S. L., Malabi, R., Maphanga, C. P., Ombinda-Lemboumba, S., Mthunzi-Kufa, P., & Nyokong, T. (2018). Evaluation of the photophysicochemical properties and photodynamic therapy activity of nanoconjugates of zinc phthalocyanine linked to glutathione capped Au and Au3Ag1 nanoparticles. http://hdl.handle.net/10204/9912 en_ZA
dc.identifier.chicagocitation Oluwole, DA, Sello L Manoto, Rudzani Malabi, Charles P Maphanga, Saturnin Ombinda-Lemboumba, Patience Mthunzi-Kufa, and T Nyokong "Evaluation of the photophysicochemical properties and photodynamic therapy activity of nanoconjugates of zinc phthalocyanine linked to glutathione capped Au and Au3Ag1 nanoparticles." (2018) http://hdl.handle.net/10204/9912 en_ZA
dc.identifier.vancouvercitation Oluwole D, Manoto SL, Malabi R, Maphanga CP, Ombinda-Lemboumba S, Mthunzi-Kufa P, et al. Evaluation of the photophysicochemical properties and photodynamic therapy activity of nanoconjugates of zinc phthalocyanine linked to glutathione capped Au and Au3Ag1 nanoparticles. 2018; http://hdl.handle.net/10204/9912. en_ZA
dc.identifier.ris TY - Article AU - Oluwole, DA AU - Manoto, Sello L AU - Malabi, Rudzani AU - Maphanga, Charles P AU - Ombinda-Lemboumba, Saturnin AU - Mthunzi-Kufa, Patience AU - Nyokong, T AB - We report on the synthesis of glutathione capped gold (AuNPs–GSH) and gold–silver (Au3Ag1NPs–GSH) nanoparticles and their covalent attachment to Zn monocarboxyphenoxy phthalocyanine (1) via amide bond formation. The photophysicochemical properties and photodynamic therapy (PDT) activity of the complex and its nanoconjugates were assessed. The conjugates afforded improved triplet and singlet oxygen quantum yield as well as PDT activity (except for 1-Au3Ag1NPs which afforded decreased activity) in comparison to complex 1. DA - 2018-03 DB - ResearchSpace DP - CSIR KW - Amide bond KW - Glutathione KW - Melanoma KW - Nanoconjugates KW - Singlet quantum yield KW - Zinc phthalocyanine LK - https://researchspace.csir.co.za PY - 2018 SM - 0143-7208 T1 - Evaluation of the photophysicochemical properties and photodynamic therapy activity of nanoconjugates of zinc phthalocyanine linked to glutathione capped Au and Au3Ag1 nanoparticles TI - Evaluation of the photophysicochemical properties and photodynamic therapy activity of nanoconjugates of zinc phthalocyanine linked to glutathione capped Au and Au3Ag1 nanoparticles UR - http://hdl.handle.net/10204/9912 ER - en_ZA


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