Evaluation of the photophysicochemical properties and photodynamic therapy activity of nanoconjugates of zinc phthalocyanine linked to glutathione capped Au and Au3Ag1 nanoparticles
Evaluation of the photophysicochemical properties and photodynamic therapy activity of nanoconjugates of zinc phthalocyanine linked to glutathione capped Au and Au3Ag1 nanoparticles
We report on the synthesis of glutathione capped gold (AuNPs–GSH) and gold–silver (Au3Ag1NPs–GSH) nanoparticles and their covalent attachment to Zn monocarboxyphenoxy phthalocyanine (1) via amide bond formation. The photophysicochemical properties and photodynamic therapy (PDT) activity of the complex and its nanoconjugates were assessed. The conjugates afforded improved triplet and singlet oxygen quantum yield as well as PDT activity (except for 1-Au3Ag1NPs which afforded decreased activity) in comparison to complex 1.
Reference:
Oluwole, D.A. et al. 2018. Evaluation of the photophysicochemical properties and photodynamic therapy activity of nanoconjugates of zinc phthalocyanine linked to glutathione capped Au and Au3Ag1 nanoparticles. Dyes and Pigments, vol. 150: 139-150
Oluwole, D., Manoto, S. L., Malabi, R., Maphanga, C. P., Ombinda-Lemboumba, S., Mthunzi-Kufa, P., & Nyokong, T. (2018). Evaluation of the photophysicochemical properties and photodynamic therapy activity of nanoconjugates of zinc phthalocyanine linked to glutathione capped Au and Au3Ag1 nanoparticles. http://hdl.handle.net/10204/9912
Oluwole, DA, Sello L Manoto, Rudzani Malabi, Charles P Maphanga, Saturnin Ombinda-Lemboumba, Patience Mthunzi-Kufa, and T Nyokong "Evaluation of the photophysicochemical properties and photodynamic therapy activity of nanoconjugates of zinc phthalocyanine linked to glutathione capped Au and Au3Ag1 nanoparticles." (2018) http://hdl.handle.net/10204/9912
Oluwole D, Manoto SL, Malabi R, Maphanga CP, Ombinda-Lemboumba S, Mthunzi-Kufa P, et al. Evaluation of the photophysicochemical properties and photodynamic therapy activity of nanoconjugates of zinc phthalocyanine linked to glutathione capped Au and Au3Ag1 nanoparticles. 2018; http://hdl.handle.net/10204/9912.
Copyright: 2017 Elsevier. Due to copyright restrictions, the attached PDF file only contains the abstract of the full text item. For access to the full text item, please consult the publisher's website.
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