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Please use this identifier to cite or link to this item: http://hdl.handle.net/10204/6396

Title: Potential of improving the treatment of tuberculosis through nanomedicine
Authors: Semete, B
Kalombo, L
Katata, L
Chelule, P
Booysen, L
Lemmer, Y
Naidoo, S
Ramalapa, B
Hayeshi, R
Swai, HS
Keywords: Drug release
Nanomedicine
PLGA nanoparticles
Tuberculosis
Issue Date: Mar-2012
Publisher: Taylor & Francis
Citation: Semete, B, Kalombo, L, Katata, L, Chelule, P, Booysen, L, Lemmer, Y, Naidoo S, Ramalapa, B, Hayeshi, R and Swai, HS. 2012. Potential of improving the treatment of tuberculosis through nanomedicine. Molecular Crystals and Liquid Crystals, Vol 556(1), pp 317-330
Series/Report no.: Workflow;8759
Abstract: Current treatment of tuberculosis is inadequate due to lengthy treatment course and drug-related toxicity. To address these setbacks, we developed a nanotechnology drug delivery system that can be administered in a single dose that maintains an active level of drug for at least a week. Polymeric poly(lactic-co-glycolic acid) nanoparticles of 200–300 nm were synthesized, with a drug encapsulation efficiency of 50–65% for isoniazid and rifampicin. The particles were taken up in vitro and in vivo and a slow release profile was observed in mice over 5 days. This study illustrates the feasibility of a sustained release system for tuberculosis treatment.
Description: Copyright: 2012 Taylor & Francis. This is the pre print version of the work. The definitive version is published in the journal of Molecular Crystals and Liquid Crystals, Vol 556(1), pp 317-330.
URI: http://www.tandfonline.com/doi/abs/10.1080/15421406.2012.635531
http://hdl.handle.net/10204/6396
ISSN: 1542-1406
Appears in Collections:Nanotechnology
General science, engineering & technology

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