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Potential of improving the treatment of tuberculosis through nanomedicine

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dc.contributor.author Semete, B
dc.contributor.author Kalombo, Lonji
dc.contributor.author Katata, L
dc.contributor.author Chelule, P
dc.contributor.author Booysen, L
dc.contributor.author Lemmer, Yolandy
dc.contributor.author Naidoo, Saloshnee
dc.contributor.author Ramalapa, B
dc.contributor.author Hayeshi, R
dc.contributor.author Swai, HS
dc.date.accessioned 2012-12-05T11:17:51Z
dc.date.available 2012-12-05T11:17:51Z
dc.date.issued 2012-03
dc.identifier.citation Semete, B., Kalombo, L., Katata, L., Chelule, P., Booysen, L., Lemmer, Y., Naidoo, S., Ramalapa, B., Hayeshi, R. and Swai, H.S. 2012. Potential of improving the treatment of tuberculosis through nanomedicine. Molecular Crystals and Liquid Crystals, Vol 556(1), pp 317-330 en_US
dc.identifier.issn 1542-1406
dc.identifier.uri http://www.tandfonline.com/doi/abs/10.1080/15421406.2012.635531
dc.identifier.uri http://hdl.handle.net/10204/6396
dc.description Copyright: 2012 Taylor & Francis. This is the pre print version of the work. The definitive version is published in the journal of Molecular Crystals and Liquid Crystals, Vol 556(1), pp 317-330. en_US
dc.description.abstract Current treatment of tuberculosis is inadequate due to lengthy treatment course and drug-related toxicity. To address these setbacks, we developed a nanotechnology drug delivery system that can be administered in a single dose that maintains an active level of drug for at least a week. Polymeric poly(lactic-co-glycolic acid) nanoparticles of 200–300 nm were synthesized, with a drug encapsulation efficiency of 50–65% for isoniazid and rifampicin. The particles were taken up in vitro and in vivo and a slow release profile was observed in mice over 5 days. This study illustrates the feasibility of a sustained release system for tuberculosis treatment. en_US
dc.language.iso en en_US
dc.publisher Taylor & Francis en_US
dc.relation.ispartofseries Workflow;8759
dc.subject Drug release en_US
dc.subject Nanomedicine en_US
dc.subject PLGA nanoparticles en_US
dc.subject Tuberculosis en_US
dc.title Potential of improving the treatment of tuberculosis through nanomedicine en_US
dc.type Article en_US
dc.identifier.apacitation Semete, B., Kalombo, L., Katata, L., Chelule, P., Booysen, L., Lemmer, Y., ... Swai, H. (2012). Potential of improving the treatment of tuberculosis through nanomedicine. http://hdl.handle.net/10204/6396 en_ZA
dc.identifier.chicagocitation Semete, B, Lonji Kalombo, L Katata, P Chelule, L Booysen, Yolandy Lemmer, Saloshnee Naidoo, B Ramalapa, R Hayeshi, and HS Swai "Potential of improving the treatment of tuberculosis through nanomedicine." (2012) http://hdl.handle.net/10204/6396 en_ZA
dc.identifier.vancouvercitation Semete B, Kalombo L, Katata L, Chelule P, Booysen L, Lemmer Y, et al. Potential of improving the treatment of tuberculosis through nanomedicine. 2012; http://hdl.handle.net/10204/6396. en_ZA
dc.identifier.ris TY - Article AU - Semete, B AU - Kalombo, Lonji AU - Katata, L AU - Chelule, P AU - Booysen, L AU - Lemmer, Yolandy AU - Naidoo, Saloshnee AU - Ramalapa, B AU - Hayeshi, R AU - Swai, HS AB - Current treatment of tuberculosis is inadequate due to lengthy treatment course and drug-related toxicity. To address these setbacks, we developed a nanotechnology drug delivery system that can be administered in a single dose that maintains an active level of drug for at least a week. Polymeric poly(lactic-co-glycolic acid) nanoparticles of 200–300 nm were synthesized, with a drug encapsulation efficiency of 50–65% for isoniazid and rifampicin. The particles were taken up in vitro and in vivo and a slow release profile was observed in mice over 5 days. This study illustrates the feasibility of a sustained release system for tuberculosis treatment. DA - 2012-03 DB - ResearchSpace DP - CSIR KW - Drug release KW - Nanomedicine KW - PLGA nanoparticles KW - Tuberculosis LK - https://researchspace.csir.co.za PY - 2012 SM - 1542-1406 T1 - Potential of improving the treatment of tuberculosis through nanomedicine TI - Potential of improving the treatment of tuberculosis through nanomedicine UR - http://hdl.handle.net/10204/6396 ER - en_ZA


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