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HIV-1 subtype C primary isolates exhibit high sensitivity to an anti-gp120 RNA aptamer

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dc.contributor.author Mufhandu, Hazel T
dc.contributor.author Alexandre, Kabamba B
dc.contributor.author Gray, ES
dc.contributor.author Morris, L
dc.contributor.author Khati, M
dc.date.accessioned 2012-11-14T08:05:03Z
dc.date.available 2012-11-14T08:05:03Z
dc.date.issued 2012-09
dc.identifier.citation Mufhandu, HT, Alexandre, KB, Gray, ES, Morris, L and Khati, M. 2012. HIV-1 subtype C primary isolates exhibit high sensitivity to an anti-gp120 RNA aptamer. Retrovirology, vol. 9 (supplement 2), p. 215 en_US
dc.identifier.issn 1742-4690
dc.identifier.uri http://www.retrovirology.com/content/pdf/1742-4690-9-S2-P215.pdf
dc.identifier.uri http://hdl.handle.net/10204/6312
dc.description Copyright: 2012 Mufhandu et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_US
dc.description.abstract Globally, HIV-1 subtype C is the most prevalent subtype, yet most antiretroviral drugs are developed against subtype B. UCLA1 RNA aptamer, which we previously showed neutralizes HIV-1 subtype C Env-pseudotyped viruses was examined for neutralization of subtype C primary isolates in PBMC and monocyte-derived macrophages (MDM). We also assessed the ability of subtype C to develop resistance to UCLA1 inhibition by propagating the isolates in increasing concentrations of the aptamer. en_US
dc.language.iso en en_US
dc.publisher BioMed Central en_US
dc.relation.ispartofseries Workflow;9652
dc.subject HIV-1 gp120 en_US
dc.subject UCLA-1 Aptamer en_US
dc.subject Antiretroviral drugs en_US
dc.title HIV-1 subtype C primary isolates exhibit high sensitivity to an anti-gp120 RNA aptamer en_US
dc.type Article en_US


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