dc.contributor.author |
Mufhandu, Hazel T
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|
dc.contributor.author |
Alexandre, Kabamba B
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|
dc.contributor.author |
Gray, ES
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dc.contributor.author |
Morris, L
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dc.contributor.author |
Khati, M
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dc.date.accessioned |
2012-11-14T08:05:03Z |
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dc.date.available |
2012-11-14T08:05:03Z |
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dc.date.issued |
2012-09 |
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dc.identifier.citation |
Mufhandu, HT, Alexandre, KB, Gray, ES, Morris, L and Khati, M. 2012. HIV-1 subtype C primary isolates exhibit high sensitivity to an anti-gp120 RNA aptamer. Retrovirology, vol. 9 (supplement 2), p. 215 |
en_US |
dc.identifier.issn |
1742-4690 |
|
dc.identifier.uri |
http://www.retrovirology.com/content/pdf/1742-4690-9-S2-P215.pdf
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dc.identifier.uri |
http://hdl.handle.net/10204/6312
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dc.description |
Copyright: 2012 Mufhandu et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
en_US |
dc.description.abstract |
Globally, HIV-1 subtype C is the most prevalent subtype, yet most antiretroviral drugs are developed against subtype B. UCLA1 RNA aptamer, which we previously showed neutralizes HIV-1 subtype C Env-pseudotyped viruses was examined for neutralization of subtype C primary isolates in PBMC and monocyte-derived macrophages (MDM). We also assessed the ability of subtype C to develop resistance to UCLA1 inhibition by propagating the isolates in increasing concentrations of the aptamer. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
BioMed Central |
en_US |
dc.relation.ispartofseries |
Workflow;9652 |
|
dc.subject |
HIV-1 gp120 |
en_US |
dc.subject |
UCLA-1 Aptamer |
en_US |
dc.subject |
Antiretroviral drugs |
en_US |
dc.title |
HIV-1 subtype C primary isolates exhibit high sensitivity to an anti-gp120 RNA aptamer |
en_US |
dc.type |
Article |
en_US |
dc.identifier.apacitation |
Mufhandu, H. T., Alexandre, K. B., Gray, E., Morris, L., & Khati, M. (2012). HIV-1 subtype C primary isolates exhibit high sensitivity to an anti-gp120 RNA aptamer. http://hdl.handle.net/10204/6312 |
en_ZA |
dc.identifier.chicagocitation |
Mufhandu, Hazel T, Kabamba B Alexandre, ES Gray, L Morris, and M Khati "HIV-1 subtype C primary isolates exhibit high sensitivity to an anti-gp120 RNA aptamer." (2012) http://hdl.handle.net/10204/6312 |
en_ZA |
dc.identifier.vancouvercitation |
Mufhandu HT, Alexandre KB, Gray E, Morris L, Khati M. HIV-1 subtype C primary isolates exhibit high sensitivity to an anti-gp120 RNA aptamer. 2012; http://hdl.handle.net/10204/6312. |
en_ZA |
dc.identifier.ris |
TY - Article
AU - Mufhandu, Hazel T
AU - Alexandre, Kabamba B
AU - Gray, ES
AU - Morris, L
AU - Khati, M
AB - Globally, HIV-1 subtype C is the most prevalent subtype, yet most antiretroviral drugs are developed against subtype B. UCLA1 RNA aptamer, which we previously showed neutralizes HIV-1 subtype C Env-pseudotyped viruses was examined for neutralization of subtype C primary isolates in PBMC and monocyte-derived macrophages (MDM). We also assessed the ability of subtype C to develop resistance to UCLA1 inhibition by propagating the isolates in increasing concentrations of the aptamer.
DA - 2012-09
DB - ResearchSpace
DP - CSIR
KW - HIV-1 gp120
KW - UCLA-1 Aptamer
KW - Antiretroviral drugs
LK - https://researchspace.csir.co.za
PY - 2012
SM - 1742-4690
T1 - HIV-1 subtype C primary isolates exhibit high sensitivity to an anti-gp120 RNA aptamer
TI - HIV-1 subtype C primary isolates exhibit high sensitivity to an anti-gp120 RNA aptamer
UR - http://hdl.handle.net/10204/6312
ER -
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en_ZA |