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Please use this identifier to cite or link to this item: http://hdl.handle.net/10204/6312

Title: HIV-1 subtype C primary isolates exhibit high sensitivity to an anti-gp120 RNA aptamer
Authors: Mufhandu, HT
Alexandre, KB
Gray, ES
Morris, L
Khati, M
Keywords: HIV-1 gp120
UCLA-1 Aptamer
Antiretroviral drugs
Issue Date: Sep-2012
Publisher: BioMed Central
Citation: Mufhandu, HT, Alexandre, KB, Gray, ES, Morris, L and Khati, M. 2012. HIV-1 subtype C primary isolates exhibit high sensitivity to an anti-gp120 RNA aptamer. Retrovirology, vol. 9 (supplement 2), p. 215
Series/Report no.: Workflow;9652
Abstract: Globally, HIV-1 subtype C is the most prevalent subtype, yet most antiretroviral drugs are developed against subtype B. UCLA1 RNA aptamer, which we previously showed neutralizes HIV-1 subtype C Env-pseudotyped viruses was examined for neutralization of subtype C primary isolates in PBMC and monocyte-derived macrophages (MDM). We also assessed the ability of subtype C to develop resistance to UCLA1 inhibition by propagating the isolates in increasing concentrations of the aptamer.
Description: Copyright: 2012 Mufhandu et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
URI: http://www.retrovirology.com/content/pdf/1742-4690-9-S2-P215.pdf
http://hdl.handle.net/10204/6312
ISSN: 1742-4690
Appears in Collections:Accessibility research
General science, engineering & technology
Aptamer technology

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