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Please use this identifier to cite or link to this item: http://hdl.handle.net/10204/5906

Title: Qualitative and quantitative intravaginal targeting: Key to anti-HIV-1 microbicide delivery from test tube to in vivo success
Authors: Pillay, V
Mashingaidze, F
Choonara, YE
Du Toit, LC
Buckmann, E
Maharaj, V
Ndesendo, VMK
Kumar, P
Keywords: Targeted drug delivery
Special populations
Site-specific delivery
Polymeric drug delivery systems
Polymer–biopolymer interactions
Physicochemical properties
Mucosal delivery
Macromolecular drug delivery
Issue Date: Jun-2012
Publisher: Wiley
Citation: Pillay, V, Mashingaidze, F, Choonara, YE, Du Toit, LC, Buckmann, E, Maharaj, V, Ndesendo, VMK and Kumar, P. 2012. Qualitative and quantitative intravaginal targeting: Key to anti-HIV-1 microbicide delivery from test tube to in vivo success. Journal of Pharmaceutical Sciences, vol. 101(6), pp 1950-1968
Series/Report no.: Workflow;8927
Abstract: The past decade has seen several effective anti-HIV-1 agent discoveries, yet microbicides continue to disappoint clinically. Our review expounds the view that unsatisfactory microbicide failures may be a result of inefficient delivery systems employed. We hereby propose a thorough scientific qualitative and quantitative investigation of important aspects involved in HIV-1 transmission as a prerequisite for microbicide delivery. Intravaginal targeting of HIV-1 increases the chances of microbicide success, wherein vaginal microenvironmental factors including pH should be maintained at HIV-1 prohibitive acidic levels simultaneously to ward off other sexually transmitted diseases, which compromise vaginal epithelial barrier properties. Furthermore, choice of receptors to target both on HIV-1 and on target cells is vital in deterring transmission. Appropriate modeling of virus–target cell interactions as well as targeting early stages of the HIV-1 infection accompanied by computation and delivery of appropriate microbicide quantities could revolutionize microbicide research, ultimately delivering a female-controlled HIV-1 prevention modality appropriately.
Description: Copyright: 2012 Wiley Periodicals, Inc. and the American Pharmacists Association. This is an ABSTRACT ONLY.
URI: http://onlinelibrary.wiley.com/doi/10.1002/jps.23098/abstract
ISSN: 0022-3549
Appears in Collections:General science, engineering & technology
General research interest

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