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In vitro anti-plasmodial activity of Dicoma anomala subsp. gerrardii (Asteraceae): identification of its main active constituent, structure-activity relationship studies and gene expression profiling

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dc.contributor.author Becker, JVW
dc.contributor.author Van der Merwe, MM
dc.contributor.author Van Brummelen, AC
dc.contributor.author Pillay, P
dc.contributor.author Crampton, BG
dc.contributor.author Mmutlane, EM
dc.contributor.author Parkinson, C
dc.contributor.author Van Heerden, FR
dc.contributor.author Crouch, NR
dc.contributor.author Smith, PJ
dc.contributor.author Mancama, Dalubuhle T
dc.contributor.author Maharaj, VJ
dc.date.accessioned 2012-03-20T15:17:08Z
dc.date.available 2012-03-20T15:17:08Z
dc.date.issued 2011-10
dc.identifier.citation Becker, JVW, Van der Merwe, MM, Van Brummelen, AC, Pillay, P, Crampton, BG, Mmutlane, EM, Parkinson, C, Van Heerden, FR, Crouch, NR, Smith, PJ, Mancama, DT and Maharaj, VJ. 2011. In vitro anti-plasmodial activity of Dicoma anomala subsp. gerrardii (Asteraceae): identification of its main active constituent, structure-activity relationship studies and gene expression profiling. Malaria Journal, vol. 10, pp 295 en_US
dc.identifier.issn 1475-2875
dc.identifier.uri http://www.malariajournal.com/content/pdf/1475-2875-10-295.pdf
dc.identifier.uri http://www.malariajournal.com/content/10/1/295
dc.identifier.uri http://hdl.handle.net/10204/5662
dc.description Copyright: 2011 The authors. en_US
dc.description.abstract Anti-malarial drug resistance threatens to undermine efforts to eliminate this deadly disease. The resulting omnipresent requirement for drugs with novel modes of action prompted a national consortium initiative to discover new anti-plasmodial agents from South African medicinal plants. One of the plants selected for investigation was Dicoma anomala subsp. gerrardii, based on its ethnomedicinal profile. en_US
dc.language.iso en en_US
dc.publisher BioMed Central en_US
dc.relation.ispartofseries Workflow;8533
dc.subject Malaria en_US
dc.subject Anti-malarial drug resistance en_US
dc.subject South African medicinal plants en_US
dc.subject Dicoma anomala subsp. gerrardii en_US
dc.subject Ethnomedicinal profile en_US
dc.subject Novel drugs en_US
dc.subject Anti-plasmodial agents en_US
dc.title In vitro anti-plasmodial activity of Dicoma anomala subsp. gerrardii (Asteraceae): identification of its main active constituent, structure-activity relationship studies and gene expression profiling en_US
dc.type Article en_US
dc.identifier.apacitation Becker, J., Van der Merwe, M., Van Brummelen, A., Pillay, P., Crampton, B., Mmutlane, E., ... Maharaj, V. (2011). In vitro anti-plasmodial activity of Dicoma anomala subsp. gerrardii (Asteraceae): identification of its main active constituent, structure-activity relationship studies and gene expression profiling. http://hdl.handle.net/10204/5662 en_ZA
dc.identifier.chicagocitation Becker, JVW, MM Van der Merwe, AC Van Brummelen, P Pillay, BG Crampton, EM Mmutlane, C Parkinson, et al "In vitro anti-plasmodial activity of Dicoma anomala subsp. gerrardii (Asteraceae): identification of its main active constituent, structure-activity relationship studies and gene expression profiling." (2011) http://hdl.handle.net/10204/5662 en_ZA
dc.identifier.vancouvercitation Becker J, Van der Merwe M, Van Brummelen A, Pillay P, Crampton B, Mmutlane E, et al. In vitro anti-plasmodial activity of Dicoma anomala subsp. gerrardii (Asteraceae): identification of its main active constituent, structure-activity relationship studies and gene expression profiling. 2011; http://hdl.handle.net/10204/5662. en_ZA
dc.identifier.ris TY - Article AU - Becker, JVW AU - Van der Merwe, MM AU - Van Brummelen, AC AU - Pillay, P AU - Crampton, BG AU - Mmutlane, EM AU - Parkinson, C AU - Van Heerden, FR AU - Crouch, NR AU - Smith, PJ AU - Mancama, Dalubuhle T AU - Maharaj, VJ AB - Anti-malarial drug resistance threatens to undermine efforts to eliminate this deadly disease. The resulting omnipresent requirement for drugs with novel modes of action prompted a national consortium initiative to discover new anti-plasmodial agents from South African medicinal plants. One of the plants selected for investigation was Dicoma anomala subsp. gerrardii, based on its ethnomedicinal profile. DA - 2011-10 DB - ResearchSpace DP - CSIR KW - Malaria KW - Anti-malarial drug resistance KW - South African medicinal plants KW - Dicoma anomala subsp. gerrardii KW - Ethnomedicinal profile KW - Novel drugs KW - Anti-plasmodial agents LK - https://researchspace.csir.co.za PY - 2011 SM - 1475-2875 T1 - In vitro anti-plasmodial activity of Dicoma anomala subsp. gerrardii (Asteraceae): identification of its main active constituent, structure-activity relationship studies and gene expression profiling TI - In vitro anti-plasmodial activity of Dicoma anomala subsp. gerrardii (Asteraceae): identification of its main active constituent, structure-activity relationship studies and gene expression profiling UR - http://hdl.handle.net/10204/5662 ER - en_ZA


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