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Show simple item record Adewusi, EA Moodley, N Steenkamp, V 2011-03-28T08:45:42Z 2011-03-28T08:45:42Z 2010-12
dc.identifier.citation Adewusi, EA, Moodley, N and Steenkamp, V. 2010. Medicinal plants with cholinesterase inhibitory activity: a review. African Journal of Biotechnology, 9(49), pp 8257-8276 en_US
dc.identifier.issn 1684-5315
dc.description Copyright: 2010 Academic Journals en_US
dc.description.abstract Alzheimer’s disease (AD), a common neurodegenerative disease, is characterized by low levels in the brain of the neurotransmitter, acetylcholine (ACh). Clinical treatment of this disease is palliative and relies mostly on enhancing cholinergic function by stimulation of cholinergic receptors or prolonging the availability of ACh released into the neuronal synaptic cleft by use of agents which restore or improve the levels of acetylcholine. Inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), enzymes which breakdown acetylcholine, are considered as a promising strategy for the treatment of AD. A potential source of AChE and BChE inhibitors is provided by the abundance of plants in nature, and natural products continue to provide useful drugs and templates for the development of other compounds. The present work constitutes a review of the literature on 123 species of medicinal plants that have been tested for AChE inhibitory activity and 42 plant species which have been tested for BChE inhibitory activity. The plant species listed are potential cholinesterase inhibitors and may aid researchers in their study of natural products which may be useful in the treatment of AD. en_US
dc.language.iso en en_US
dc.publisher Academic Journals en_US
dc.relation.ispartofseries Workflow;6030
dc.subject Alzheimer’s disease en_US
dc.subject Acetylcholine en_US
dc.subject Acetylcholinesterase en_US
dc.subject Neurodegenerative diseases en_US
dc.subject Butyrylcholinesterase en_US
dc.subject Medicinal plants en_US
dc.subject Biotechnology en_US
dc.title Medicinal plants with cholinesterase inhibitory activity: a review en_US
dc.type Article en_US

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