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Please use this identifier to cite or link to this item: http://hdl.handle.net/10204/4923

Title: Medicinal plants with cholinesterase inhibitory activity: a review
Authors: Adewusi, EA
Moodley, N
Steenkamp, V
Keywords: Alzheimer’s disease
Acetylcholine
Acetylcholinesterase
Neurodegenerative diseases
Butyrylcholinesterase
Medicinal plants
Biotechnology
Issue Date: Dec-2010
Publisher: Academic Journals
Citation: Adewusi, EA, Moodley, N and Steenkamp, V. 2010. Medicinal plants with cholinesterase inhibitory activity: a review. African Journal of Biotechnology, 9(49), pp 8257-8276
Series/Report no.: Workflow;6030
Abstract: Alzheimer’s disease (AD), a common neurodegenerative disease, is characterized by low levels in the brain of the neurotransmitter, acetylcholine (ACh). Clinical treatment of this disease is palliative and relies mostly on enhancing cholinergic function by stimulation of cholinergic receptors or prolonging the availability of ACh released into the neuronal synaptic cleft by use of agents which restore or improve the levels of acetylcholine. Inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), enzymes which breakdown acetylcholine, are considered as a promising strategy for the treatment of AD. A potential source of AChE and BChE inhibitors is provided by the abundance of plants in nature, and natural products continue to provide useful drugs and templates for the development of other compounds. The present work constitutes a review of the literature on 123 species of medicinal plants that have been tested for AChE inhibitory activity and 42 plant species which have been tested for BChE inhibitory activity. The plant species listed are potential cholinesterase inhibitors and may aid researchers in their study of natural products which may be useful in the treatment of AD.
Description: Copyright: 2010 Academic Journals
URI: http://www.academicjournals.org/AJB/PDF/pdf2010/6Dec/Adewusi%20et%20al.pdf
http://hdl.handle.net/10204/4923
ISSN: 1684-5315
Appears in Collections:General science, engineering & technology
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