dc.contributor.author |
Van de Venter, M
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dc.contributor.author |
Roux, S
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dc.contributor.author |
Bungu, LC
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dc.contributor.author |
Louw, J
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dc.contributor.author |
Crouch, NR
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dc.contributor.author |
Grace, OM
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dc.contributor.author |
Maharaj, V
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dc.contributor.author |
Pillay, P
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dc.contributor.author |
Sewnarian, P
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dc.contributor.author |
Bhagwandin, N
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dc.contributor.author |
Folb, P
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dc.date.accessioned |
2009-05-18T10:52:53Z |
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dc.date.available |
2009-05-18T10:52:53Z |
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dc.date.issued |
2008-09 |
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dc.identifier.citation |
Van de Venter, M, Roux, S, Bungu, LC et al. 2008. Antidiabetic screening and scoring of eleven plants traditionally used in South Africa. Journal of Ethnopharmacology, Vol. (2008), pp 27 |
en |
dc.identifier.issn |
0378-8741 |
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dc.identifier.uri |
http://hdl.handle.net/10204/3381
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dc.description |
Author Posting. Copyright Elsevier, 2008. This is the author's version of the work. It is posted here by permission of Elsevier for personal use, not for redistribution |
en |
dc.description.abstract |
The aim of the paper is to investigate the traditional antidiabetic uses of indigenous or naturalised South African plants using an optimised screening and scoring method. Eleven plant species were screened against Chang liver, 3T3-L1 adipose and C2C12 muscle cells measuring glucose utilisation in all three cell lines and toxicity in the hepatocytes and adipocytes only. A scoring system was devised to aid interpretation of results. Catharanthus roseus results correlated with previously reported in vivo results, with best stimulation of glucose utilisation in hepatocytes. Momordica foetida and Momordica balsamina extracts were active in myocytes but only the latter stimulated glucose utilisation in hepatocytes. Brachylaena discolor gave the best overall results, with all plant parts giving high activity scores and negligible toxicity. In vitro toxicity results for Catharanthus roseus, Vinca major, Momordica balsamina and some Sclerocarya birrea extracts raise concern for chronic use. This screening system increases the likelihood of identifying drug candidates using in vitro antidiabetic screening of crude plant extracts, whilst the scoring system aids data interpretation. Ethnopharmacological relevance: The multitude of metabolic steps affected by Type II diabetes offer many drug targets but they complicate in vitro screening to validate traditional uses or find newdrug leads from plants. |
en |
dc.language.iso |
en |
en |
dc.publisher |
Elsevier |
en |
dc.subject |
Medicinal plants |
en |
dc.subject |
Glucose utilisation |
en |
dc.subject |
Chang liver |
en |
dc.subject |
South Africa |
en |
dc.subject |
3T3-L1 adipose |
en |
dc.subject |
C2C12 muscle cells |
en |
dc.subject |
Antidiabetic |
en |
dc.subject |
Plant extracts |
en |
dc.subject |
Indigenous plants |
en |
dc.subject |
Diabetes discovery platform |
en |
dc.title |
Antidiabetic screening and scoring of eleven plants traditionally used in South Africa |
en |
dc.type |
Article |
en |
dc.identifier.apacitation |
Van de Venter, M., Roux, S., Bungu, L., Louw, J., Crouch, N., Grace, O., ... Folb, P. (2008). Antidiabetic screening and scoring of eleven plants traditionally used in South Africa. http://hdl.handle.net/10204/3381 |
en_ZA |
dc.identifier.chicagocitation |
Van de Venter, M, S Roux, LC Bungu, J Louw, NR Crouch, OM Grace, V Maharaj, et al "Antidiabetic screening and scoring of eleven plants traditionally used in South Africa." (2008) http://hdl.handle.net/10204/3381 |
en_ZA |
dc.identifier.vancouvercitation |
Van de Venter M, Roux S, Bungu L, Louw J, Crouch N, Grace O, et al. Antidiabetic screening and scoring of eleven plants traditionally used in South Africa. 2008; http://hdl.handle.net/10204/3381. |
en_ZA |
dc.identifier.ris |
TY - Article
AU - Van de Venter, M
AU - Roux, S
AU - Bungu, LC
AU - Louw, J
AU - Crouch, NR
AU - Grace, OM
AU - Maharaj, V
AU - Pillay, P
AU - Sewnarian, P
AU - Bhagwandin, N
AU - Folb, P
AB - The aim of the paper is to investigate the traditional antidiabetic uses of indigenous or naturalised South African plants using an optimised screening and scoring method. Eleven plant species were screened against Chang liver, 3T3-L1 adipose and C2C12 muscle cells measuring glucose utilisation in all three cell lines and toxicity in the hepatocytes and adipocytes only. A scoring system was devised to aid interpretation of results. Catharanthus roseus results correlated with previously reported in vivo results, with best stimulation of glucose utilisation in hepatocytes. Momordica foetida and Momordica balsamina extracts were active in myocytes but only the latter stimulated glucose utilisation in hepatocytes. Brachylaena discolor gave the best overall results, with all plant parts giving high activity scores and negligible toxicity. In vitro toxicity results for Catharanthus roseus, Vinca major, Momordica balsamina and some Sclerocarya birrea extracts raise concern for chronic use. This screening system increases the likelihood of identifying drug candidates using in vitro antidiabetic screening of crude plant extracts, whilst the scoring system aids data interpretation. Ethnopharmacological relevance: The multitude of metabolic steps affected by Type II diabetes offer many drug targets but they complicate in vitro screening to validate traditional uses or find newdrug leads from plants.
DA - 2008-09
DB - ResearchSpace
DP - CSIR
KW - Medicinal plants
KW - Glucose utilisation
KW - Chang liver
KW - South Africa
KW - 3T3-L1 adipose
KW - C2C12 muscle cells
KW - Antidiabetic
KW - Plant extracts
KW - Indigenous plants
KW - Diabetes discovery platform
LK - https://researchspace.csir.co.za
PY - 2008
SM - 0378-8741
T1 - Antidiabetic screening and scoring of eleven plants traditionally used in South Africa
TI - Antidiabetic screening and scoring of eleven plants traditionally used in South Africa
UR - http://hdl.handle.net/10204/3381
ER -
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en_ZA |