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Show simple item record Van de Venter, M Roux, S Bungu, LC Louw, J Crouch, NR Grace, OM Maharaj, V Pillay, P Sewnarian, P Bhagwandin, N Folb, P 2009-05-18T10:52:53Z 2009-05-18T10:52:53Z 2008-09
dc.identifier.citation Van de Venter, M, Roux, S, Bungu, LC et al. 2008. Antidiabetic screening and scoring of eleven plants traditionally used in South Africa. Journal of Ethnopharmacology, Vol. (2008), pp 27 en
dc.identifier.issn 0378-8741
dc.description Author Posting. Copyright Elsevier, 2008. This is the author's version of the work. It is posted here by permission of Elsevier for personal use, not for redistribution en
dc.description.abstract The aim of the paper is to investigate the traditional antidiabetic uses of indigenous or naturalised South African plants using an optimised screening and scoring method. Eleven plant species were screened against Chang liver, 3T3-L1 adipose and C2C12 muscle cells measuring glucose utilisation in all three cell lines and toxicity in the hepatocytes and adipocytes only. A scoring system was devised to aid interpretation of results. Catharanthus roseus results correlated with previously reported in vivo results, with best stimulation of glucose utilisation in hepatocytes. Momordica foetida and Momordica balsamina extracts were active in myocytes but only the latter stimulated glucose utilisation in hepatocytes. Brachylaena discolor gave the best overall results, with all plant parts giving high activity scores and negligible toxicity. In vitro toxicity results for Catharanthus roseus, Vinca major, Momordica balsamina and some Sclerocarya birrea extracts raise concern for chronic use. This screening system increases the likelihood of identifying drug candidates using in vitro antidiabetic screening of crude plant extracts, whilst the scoring system aids data interpretation. Ethnopharmacological relevance: The multitude of metabolic steps affected by Type II diabetes offer many drug targets but they complicate in vitro screening to validate traditional uses or find newdrug leads from plants. en
dc.language.iso en en
dc.publisher Elsevier en
dc.subject Medicinal plants en
dc.subject Glucose utilisation en
dc.subject Chang liver en
dc.subject South Africa en
dc.subject 3T3-L1 adipose en
dc.subject C2C12 muscle cells en
dc.subject Antidiabetic en
dc.subject Plant extracts en
dc.subject Indigenous plants en
dc.subject Diabetes discovery platform en
dc.title Antidiabetic screening and scoring of eleven plants traditionally used in South Africa en
dc.type Article en

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