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Please use this identifier to cite or link to this item: http://hdl.handle.net/10204/3381

Title: Antidiabetic screening and scoring of eleven plants traditionally used in South Africa
Authors: Van de Venter, M
Roux, S
Bungu, LC
Louw, J
Crouch, NR
Grace, OM
Maharaj, V
Pillay, P
Sewnarian, P
Bhagwandin, N
Folb, P
Keywords: Medicinal plants
Glucose utilisation
Chang liver
South Africa
3T3-L1 adipose
C2C12 muscle cells
Antidiabetic
Plant extracts
Indigenous plants
Diabetes discovery platform
Issue Date: Sep-2008
Publisher: Elsevier
Citation: Van de Venter, M, Roux, S, Bungu, LC et al. 2008. Antidiabetic screening and scoring of eleven plants traditionally used in South Africa. Journal of Ethnopharmacology, Vol. (2008), pp 27
Abstract: The aim of the paper is to investigate the traditional antidiabetic uses of indigenous or naturalised South African plants using an optimised screening and scoring method. Eleven plant species were screened against Chang liver, 3T3-L1 adipose and C2C12 muscle cells measuring glucose utilisation in all three cell lines and toxicity in the hepatocytes and adipocytes only. A scoring system was devised to aid interpretation of results. Catharanthus roseus results correlated with previously reported in vivo results, with best stimulation of glucose utilisation in hepatocytes. Momordica foetida and Momordica balsamina extracts were active in myocytes but only the latter stimulated glucose utilisation in hepatocytes. Brachylaena discolor gave the best overall results, with all plant parts giving high activity scores and negligible toxicity. In vitro toxicity results for Catharanthus roseus, Vinca major, Momordica balsamina and some Sclerocarya birrea extracts raise concern for chronic use. This screening system increases the likelihood of identifying drug candidates using in vitro antidiabetic screening of crude plant extracts, whilst the scoring system aids data interpretation. Ethnopharmacological relevance: The multitude of metabolic steps affected by Type II diabetes offer many drug targets but they complicate in vitro screening to validate traditional uses or find newdrug leads from plants.
Description: Author Posting. Copyright Elsevier, 2008. This is the author's version of the work. It is posted here by permission of Elsevier for personal use, not for redistribution
URI: http://hdl.handle.net/10204/3381
ISSN: 0378-8741
Appears in Collections:General science, engineering & technology
Bioprospecting
Discovery chemistry

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