Author:Pillay, P; Maharaj, VJ; Clarkson, C; Chibale, KDate:Jan 2007Malaria is the leading cause of death and disease worldwide. The evolution and spread of drug-resistant forms of the causative agent Plasmodium falciparum and the limited number of chemotherapeutic agents available to treat and control the ...Read more
Author:Maharaj, R; Gayaram, R; Crouch, N; Maharaj, V; Pillay, P; Bhagwandin, N; Folb, PIDate:Feb 2006Malaria is a serious health problem in South Africa affecting the lives of approximately 4 million people. Resistance to the principal vector, Anopheles arabiensis, has initiated a search for new plant-derived insecticides. Plants were selected ...Read more
Author:Becker, J; Mtwisha, L; Crampton, B; Mancama, Dalubuhle TDate:Nov 2008Malaria is one of the world's most important tropical diseases, killing more than a million of an estimated 300-500 million infected people per annum. The species responsible for the most fatalities amongst the genus is Plasmodium falsiparum. ...Read more
Author:Van Brummelen, AC; Becker, JVW; Mancama, Dalubuhle T; Hoppe, HDate:Jan 2010In order to establish malaria parasite transfection technology in South Africa, firefly luciferase and green fluorescent protein (GFP) reporter constructs were prepared. In attempt to simplify these constructs, a var intron (PFC0005w), ...Read more
Author:Setshedi, I; Peter, Xolani K; Fouché, Gerda; Myer, M; Dewar, JDate:01 Sep 2010The genus Sceletium is classified as part of the Family Mesembryanthemaceae and belongs to the sub-family Mesembryanthemoideae. Some of the names used when referring to this genus are ‘living skeletons’ or ‘skeleton plants’ (http://ujdigisp ...Read more
Author:Tsekoa, Tsepo LDate:Oct 2009Malaria continues to be one of the most serious global health challenges. The increasing incidence of drug resistant Plasmodium strains has emphasised the need for urgent action in the development of new therapeutic strategies against this ...Read more
Author:Tsekoa, Tsepo L; Makungo, T; Mancama, Dalubuhle TDate:Jul 2012Malaria continues to be one of the most serious global health challenges. The increasing incidence of drug resistant Plasmodium strains has emphasised the need for urgent action in the development of new therapeutic strategies against this ...Read more
Author:Swai, HSDate:Oct 2012The author is the principal investigator of the TB Nano drug delivery project which is now going through pre-clinical trials with exciting results, and in this presentation the insights based on the case study will be shared.Read more
Author:Rossouw, C; Chetty, A; Moolman, S; Hoppe, H; Birkholtz, L; Mancama, Dalubuhle TDate:Feb 2010Much research remains to be done in order to understand the Plasmodium-liver interaction process. While previous in vitro studies have focused on two-dimensional (2D) cell culture, it is becoming more evident to researchers that the context ...Read more
Author:Moleele, SS; Gravestock, D; Rousseau, AL; Van Zyl, RLDate:Sep 2008Malaria causes the death of 2-3 million people annually, most of these children under 5 years of age. Approximately 300 million cases of acute malaria are reported each year, 90% of these in Africa. Until recently, folate metabolism has been ...Read more