Browsing Conference Publications by Subject "Malaria"

Now showing items 1-11 of 11

Antimalarial properties of South African medicinal plants

Author: Pillay, P ; Maharaj, VJ ; Clarkson, C ; Chibale, K Date: Jan 2007 Malaria is the leading cause of death and disease worldwide. The evolution and spread of drug-resistant forms of the causative agent Plasmodium falciparum and the limited number of chemotherapeutic agents available to treat and control the ... Read more
Bio-evaluation of South African plants for insecticidal properties

Author: Maharaj, R ; Gayaram, R ; Crouch, N ; Maharaj, V ; Pillay, P ; Bhagwandin, N ; Folb, PI Date: Feb 2006 Malaria is a serious health problem in South Africa affecting the lives of approximately 4 million people. Resistance to the principal vector, Anopheles arabiensis, has initiated a search for new plant-derived insecticides. Plants were selected ... Read more
Elucidating antimalarial drug targets/mode-of-action by application of system biology technologies

Author: Becker, J ; Mtwisha, L ; Crampton, B ; Mancama, Dalubuhle T Date: Nov 2008 Malaria is one of the world's most important tropical diseases, killing more than a million of an estimated 300-500 million infected people per annum. The species responsible for the most fatalities amongst the genus is Plasmodium falsiparum. ... Read more
Establishing malaria parasite transfection technology in South Africa.

Author: Van Brummelen, AC ; Becker, JVW ; Mancama, Dalubuhle T ; Hoppe, H Date: Jan 2010 In order to establish malaria parasite transfection technology in South Africa, firefly luciferase and green fluorescent protein (GFP) reporter constructs were prepared. In attempt to simplify these constructs, a var intron (PFC0005w), ... Read more
Isolation of compounds from Sceletium tortuosum and the detection of antimalarial activity of the isolates and extracts

Author: Setshedi, I ; Peter, Xolani K ; Fouché, Gerda ; Myer, M ; Dewar, J Date: 01 Sep 2010 The genus Sceletium is classified as part of the Family Mesembryanthemaceae and belongs to the sub-family Mesembryanthemoideae. Some of the names used when referring to this genus are ‘living skeletons’ or ‘skeleton plants’ (http://ujdigisp ... Read more
Molecular modelling of calcium dependent protein kinase 4 (CDPK4) from Plasmodium falciparum

Author: Tsekoa, Tsepo L Date: Oct 2009 Malaria continues to be one of the most serious global health challenges. The increasing incidence of drug resistant Plasmodium strains has emphasised the need for urgent action in the development of new therapeutic strategies against this ... Read more
Molecular Modelling of Calcium Dependent Protein Kinase 4 (CDPK4) from Plasmodium falciparum

Author: Tsekoa, Tsepo L ; Makungo, T ; Mancama, Dalubuhle T Date: Jul 2012 Malaria continues to be one of the most serious global health challenges. The increasing incidence of drug resistant Plasmodium strains has emphasised the need for urgent action in the development of new therapeutic strategies against this ... Read more
Nanomedicine: Recent developments and opportunities in Africa

Author: Swai, HS Date: Oct 2012 The author is the principal investigator of the TB Nano drug delivery project which is now going through pre-clinical trials with exciting results, and in this presentation the insights based on the case study will be shared. Read more
Optimization of an in vitro system to study the exo-erythrocytic stage of the human malaria parasite, Plasmodium falciparum

Author: Rossouw, C ; Chetty, A ; Moolman, S ; Hoppe, H ; Birkholtz, L ; Mancama, Dalubuhle T Date: Feb 2010 Much research remains to be done in order to understand the Plasmodium-liver interaction process. While previous in vitro studies have focused on two-dimensional (2D) cell culture, it is becoming more evident to researchers that the context ... Read more
Pyrimidines in antimalarial drug design

Author: Moleele, SS ; Gravestock, D ; Rousseau, AL ; Van Zyl, RL Date: Sep 2008 Malaria causes the death of 2-3 million people annually, most of these children under 5 years of age. Approximately 300 million cases of acute malaria are reported each year, 90% of these in Africa. Until recently, folate metabolism has been ... Read more
South African plants as a source of drugs to treat infectious diseases - TB, malaria and HIV.

Author: Pillay, P ; Naidoo, Dashnie ; Maharaj, VJ ; Moodley, N ; Sewnarain, P ; Van Rooyen, S ; Mthembu, X ; Khorombi, E Date: Nov 2008 CSIR Biosciences is actively involved in identifying new medicines effective against tuberculosis (TB), malaria and HIV based on South Africa’s rich biodiversity. As part of a national multidisciplinary consortium, the Bioprospecting research ... Read more

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Browsing Conference Publications by Subject "Malaria"

Browsing Conference Publications by Subject "Malaria"

Browse

All of ResearchSpace

This Collection

Quick Links

Legislation and compliance

General Enquiries

Social Connect