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Please use this identifier to cite or link to this item: http://hdl.handle.net/10204/3321

Title: Pyrimidines in antimalarial drug design
Authors: Moleele, SS
Gravestock, D
Rousseau, AL
Van Zyl, RL
Keywords: Antimalarial drugs
Pyrimidines
Malaria
Plasmodium falciparum dihydrofolate reductase-thymidylate synthase
PfDHFR-TS
Malaria chemotherapy
Anti-DHFR drugs
SACI-GDCh Bi-National Organic Chemistry Conference 2008
Issue Date: Sep-2008
Publisher: SACI-GDCh Bi-National Organic Chemistry Conference 2008
Citation: Moleele, SS, Gravestock, D, Rousseau, AL and Van Zyl, RL. 2008. Pyrimidines in antimalarial drug designSACI-GDCh Bi-National Organic Chemistry Conference 2008. Incorporating the 10th Frank Warren Conference, Kruger National Park, South Africa, 14-19 September 2008, pp 1
Abstract: Malaria causes the death of 2-3 million people annually, most of these children under 5 years of age. Approximately 300 million cases of acute malaria are reported each year, 90% of these in Africa. Until recently, folate metabolism has been successfully targeted in both prophylaxis and treatment of malaria. Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) is a well defined and validated target for malaria chemotherapy. Unfortunately, resistance to the most commonly used anti-DHFR drugs, including pyrimethamine 1 now limits the clinical usefulness of these drugs
Description: SACI-GDCh Bi-National Organic Chemistry Conference '08 Incorporating the 10th Frank Warren Conference, Kruger National Park, South Africa, 14-19 September 2008
URI: http://hdl.handle.net/10204/3321
Appears in Collections:General science, engineering & technology
Discovery chemistry

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