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Browsing Research Publications/Outputs by Author "Labuschagne, Philip W"

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CO2-assisted production of polyethylene glycol / lauric acid microparticles for extended release of Citrus aurantifolia essential oil

Author: Akolade, Jubril O ; Olubukola Nasir-Naeem, K ; Swanepoel, Andri ; Yusuf, AA ; Balogun, Mohammed O ; Labuschagne, Philip W Date: May 2020 Applications of essential oils as chemotherapeutics are limited because these aromatic oils are generally volatile, insoluble in aqueous media and easily degraded to non-active constituents when subjected to thermal-oxidative processes. The ... Read more
Compatibility of polyvinyl alcohol and poly(methyl vinyl ether-co-maleic acid) blends estimated by molecular dynamics

Author: Moolman, FS ; Meunier, M ; Labuschagne, Philip W ; Truter, PA Date: 25 Jul 2005 The CSIR has developed a novel oxygen barrier technology for plastics packaging based on interpolymer complex formation between PVOH (polyvinyl alcohol) and PMVE-MA (poly(methyl vinyl ether-co-maleic acid)). As interpolymer complexation ... Read more
Dammarane-type triterpenoids with anti-cancer activity from the leaves of Cleome gynandra

Author: Mzondo, Buntubonke ; Dlamini, Nomusa ; Malan, FP ; Labuschagne, Philip W ; Bovilla, VR ; Madhunapantula, SV ; Maharaj, V Date: Jun 2021 Three dammarane-type triterpernoids including two new ones, cleogynones A and B (1 and 2), were isolated from the leaves of Cleome gynandra. The structures of the new triterpenoids were elucidated by spectroscopic data analysis and confirmed ... Read more
Encapsulating probiotics with an interpolymer complex in supercritical carbon dioxide

Author: Moolman, FS ; Labuschagne, Philip W ; Thantsa, MS ; Van der Merwe, TL ; Rolfes, H ; Cloete, TE Date: 2006 Traditional encapsulation methods in fortified foods and drug delivery applications present difficulties for ‘actives’, such as probiotics, sensitive to exposure to water, solvents, heat or oxygen, where ‘active’ refers to a material, chemical ... Read more
Formation of an interpolymer complex in supercritical carbon dioxide and its application in the encapsulation of probiotics

Author: Moolman, S ; Labuschagne, Philip W ; Thantsha, MS ; Van der Merwe, TL ; Cloete, TE Date: 27 Feb 2006 Traditional encapsulation methods present difficulties for sensitive actives such as probiotics, due to exposure to water/solvents, heat, oxygen, etc. The authors present a novel encapsulation technology utilising the formation of an interpolymer ... Read more
Impact of wall material physicochemical characteristics on the stability of encapsulated phytochemicals: A review

Author: Labuschagne, Philip W Date: May 2018 Phytochemicals are plant-derived chemicals that have a number of protective or health-promoting properties. However, their health benefits and thus commercial potential can be restricted due to their instability to environmental factors such ... Read more
In situ FTIR spectroscopic study of the effect of CO2 sorption on H-bonding in PEG–PVP mixtures

Author: Labuschagne, Philip W ; Kazarian, SG ; Sadiku, RE Date: May 2011 A study of the H-bonding between poly(ethylene glycol) (PEG) and polyvinylpyrrolidone (PVP) in the presence of supercritical carbon dioxide at various temperatures, pressures, different M(w) of PEG and PVP and different PEG/PVP ratios is ... Read more
Investigation of the degree of homogeneity and hydrogen bonding in PEG/PVP blends prepared in supercritical CO2: comparison with ethanol-cast blends and physical mixtures

Author: Labuschagne, Philip W ; John, Maya J ; Sadiku, RE Date: Jul 2010 The degree of homogeneity and H-bond interaction in blends of low-molecular-mass poly(ethylene glycols) (PEG, Mw = 400, 600, 1000) and poly(vinylpyrrolidone) (PVP, Mw =9×103) prepared in supercritical CO2, ethanol and as physical mixtures ... Read more
Microencapsulation of eucalyptol in polyethylene glycol and polycaprolactone using particles from gas-saturated solutions

Author: Akolade, Jubril O ; Balogun, Mohammed O ; Swanepoel, Andri ; Ibrahim, RB ; Yusuf, AA ; Labuschagne, Philip W Date: Oct 2019 Eucalyptol is the natural cyclic ether which constitutes the bulk of terpenoids found in essential oils of Eucalyptus spp. and is used in aromatherapy for treatment of migraine, sinusitis, asthma and stress. It acts by inhibiting arachidonic ... Read more
Micronization, characterization and in-vitro dissolution of shellac from PGSS supercritical CO2 technique

Author: Labuschagne, Philip W ; Naicker, B ; Kalombo, Lonji Date: Feb 2016 The purpose of this investigation was to determine whether shellac, a naturally occurring material with enteric properties, could be processed in supercritical CO2 (sc-CO2) using the particles from gas saturated solution (PGSS) process and ... Read more
Novel encapsulation method for probiotics using an interpolymer complex in supercriticial carbon dioxide

Author: Moolman, FS ; Labuschagne, Philip W ; Thantsha, MS ; Van Der Merwe, TL ; Rolfes, H ; Cloete, TE Date: Oct 2006 The CSIR has developed a novel scCO2-based encapsulation technology utilizing interpolymer complex formation to improve the barrier properties of the polymer system. In this paper the auhtors report some results obtained in the application ... Read more
Polymer/layered silicates nanocomposites for barrier technology

Author: Labuschagne, Philip W ; Moolman, S ; Maity, Arjun Date: Feb 2012 Plastics are used increasingly in packaging applications due to a number of favorable properties, such as versatility, low weight, and low cost. However, their biggest drawback when compared to traditional packaging materials, such as glass ... Read more
Preclinical assessment of 68Ga-PSMA-617 entrapped in a microemulsion delivery system for applications in prostate cancer PET/CT imaging

Author: Mandiwana, Vusani ; Kalombo, Lonji ; Lemmer, Yolandy ; Labuschagne, Philip W ; Semete-Makokotlela, Boitumelo ; Sathekge, M ; Ebenhan, T ; Rijn Zeevaart, J Date: Jun 2019 It has in recent years been reported that microemulsion (ME) delivery systems provide an opportunity to improve the efficacy of a therapeutic agent whilst minimising side effects and also offer the advantage of favourable treatment regimens. ... Read more
Preparation of rifampicin/poly(d,l-lactice) nanoparticles for sustained release by supercritical assisted atomization technique

Author: Labuschagne, Philip W ; Adami, R ; Liparoti, S ; Naidoo, Saloshnee ; Swai, H ; Reverchon, E Date: Nov 2014 In this work supercritical assisted atomization (SAA) process was used for the co-precipitation of poly(d,l-lactide) (PDLLA) and rifampicin (RIF) as nanoparticles for sustained release applications. The effect of the variation of PDLLA/RIF ... Read more
Supercritical antisolvent co-precipitation of rifampicin and ethyl cellulose

Author: Djerafi, R ; Swanepoel, Andri ; Crampon, C ; Kalombo, Lonji ; Labuschagne, Philip W ; Badens, E ; Masmoudi, Y Date: May 2017 Rifampicin-loaded submicron-sized particles were prepared through supercritical anti-solvent process using ethyl cellulose as polymeric encapsulating excipient. Ethyl acetate and a mixture of ethyl acetate/dimethyl sulfoxide (70/30 and 85/15) ... Read more
Supercritical CO2 interpolymer complex encapsulation improves heat stability of probiotic bifidobacteria

Author: Thantsha, MS ; Labuschagne, Philip W ; Mamvura, CI Date: Feb 2014 The probiotic industry faces the challenge of retention of probiotic culture viability as numbers of these cells within their products inevitably decrease over time. In order to retain probiotic viability levels above the therapeutic minimum ... Read more
Supercritical CO2-assisted preparation of ibuprofen loaded PEG-PVP complexes

Author: Labuschagne, Philip W ; Kazarian, SG ; Sadiku, RE Date: Jun 2010 Stoichiometric ratios of poly (ethylene glycol) (PEG, Mw = 400) with poly(vinylpyrrolidone) (PVP, Mw = ±3.1 x 104 & Mw = 1.25 x 106 Mw) were prepared from ethanol cast solutions and in supercritical CO2. The complex formation was studied via ... Read more
Supercritical CO2: a ‘green’ route for the encapsulation of drugs

Author: Labuschagne, Philip W Date: 01 Sep 2010 Supercritical Carbon-dioxide (CO2) is fast becoming an important commercial and industrial solvent of choice, largely due to its solvating efficiency and low environmental impact. In many instances, supercritical CO2 can replace the use of ... Read more
Survival of B. longum Bb-46 in simulated gastrointestinal fluids

Author: Thantsha, MS ; Cloete, TE ; Moolman, FS ; Labuschagne, Philip W Date: Jan 2009 Gastric acidity is the main factor affecting viability of probiotics in the gastrointestinal tract (GIT). This study investigated the survival in simulated gastrointestinal fluids of Bifidobacterium longum Bb-46 encapsulated in interpolymer ... Read more
Synthesis, characterization and in vitro cytotoxicity evaluation of polyamidoamine conjugate containing pamidronate and platinum drug

Author: Ndamase, AS ; Aderibigbe, BA ; Sadiku, ER ; Labuschagne, Philip W ; Lemmer, Yolandy ; Ray, Suprakas S ; Nwamadi, M Date: Feb 2018 Bisphosphonates have been found to be effective when combined with anticancer drugs for chemotherapy. In this paper, pamidronate and platinum complexes were conjugated to linear poly(amidoamine)s (PAMAM) to improve the drug efficacy. The ... Read more

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