Three dammarane-type triterpernoids including two new ones, cleogynones A and B (1 and 2), were isolated from the leaves of Cleome gynandra. The structures of the new triterpenoids were elucidated by spectroscopic data analysis and confirmed by single crystal X-ray crystallography. All three compounds showed moderate cytotoxicity against breast cancer (MDA-MB-468), cleogynone B (2) and compound (3) further showed cytotoxicity against colorectal cancer (HCT-116 & HCT-15). Cleogynone B was also moderately active against lung cancer (A549).
Reference:
Mzondo, B., Dlamini, N., Malan, F., Labuschagne, P.W., Bovilla, V., Madhunapantula, S. & Maharaj, V. 2021. Dammarane-type triterpenoids with anti-cancer activity from the leaves of Cleome gynandra. Phytochemistry Letters, 43. http://hdl.handle.net/10204/12119
Mzondo, B., Dlamini, N., Malan, F., Labuschagne, P. W., Bovilla, V., Madhunapantula, S., & Maharaj, V. (2021). Dammarane-type triterpenoids with anti-cancer activity from the leaves of Cleome gynandra. Phytochemistry Letters, 43, http://hdl.handle.net/10204/12119
Mzondo, Buntubonke, Nomusa Dlamini, FP Malan, Philip W Labuschagne, VR Bovilla, SV Madhunapantula, and V Maharaj "Dammarane-type triterpenoids with anti-cancer activity from the leaves of Cleome gynandra." Phytochemistry Letters, 43 (2021) http://hdl.handle.net/10204/12119
Mzondo B, Dlamini N, Malan F, Labuschagne PW, Bovilla V, Madhunapantula S, et al. Dammarane-type triterpenoids with anti-cancer activity from the leaves of Cleome gynandra. Phytochemistry Letters, 43. 2021; http://hdl.handle.net/10204/12119.
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