A commercial laccase, Suberase from Novozymes, catalyses the synthesis of triaminated cyclohexa-2,4-dienones and a methylbenzene-1,2-diol derivative. The primary amine (analine) and the catechol was reacted under mild conditions (40C) in a reaction vessel open to air in the presence of Suberase and a co-solvent (DMF) at pH 6.0. This reaction was also conducted using an environmentally friendly cosolvent (EtOH). Triamination is favoured over diamination and monoamination.
Reference:
Wellington, K.W., Govindjee, V.P., Steenkamp, P. 2018. A laccase-catalysed synthesis of triaminated cyclohexa-2,4-dienones from catechol. Journal of Catalysis, v. 368, pp 306-314.
Wellington, K. W., Govindjee, V. P., & Steenkamp, P. (2018). A laccase-catalysed synthesis of triaminated cyclohexa-2,4-dienones from catechol. http://hdl.handle.net/10204/10753
Wellington, Kevin W, Varsha P Govindjee, and Paul Steenkamp "A laccase-catalysed synthesis of triaminated cyclohexa-2,4-dienones from catechol." (2018) http://hdl.handle.net/10204/10753
Wellington KW, Govindjee VP, Steenkamp P. A laccase-catalysed synthesis of triaminated cyclohexa-2,4-dienones from catechol. 2018; http://hdl.handle.net/10204/10753.
Copyright: 2018 Elsevier. Due to copyright restrictions, the attached PDF file contains the abstract of the published item only. For access to the published item, kindly consult the publisher's website. The definitive version of the is published at https://doi.org/10.1016/j.jcat.2018.10.014
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