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Functionalization of PLGA Nanoparticles with 1,3-ß-glucan Enhances the Intracellular Pharmacokinetics of Rifampicin in Macrophages
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| dc.contributor.author |
Tukulula, M
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| dc.contributor.author |
Gouveia, L
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| dc.contributor.author |
Paixao, P
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| dc.contributor.author |
Hayeshi, R
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| dc.contributor.author |
Naicker, Brendon
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| dc.contributor.author |
Dube, A
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| dc.date.accessioned | 2018-08-23T08:55:06Z | |
| dc.date.available | 2018-08-23T08:55:06Z | |
| dc.date.issued | 2018-06 | |
| dc.identifier.citation | Tukulula, M. et al. 2018. Functionalization of PLGA Nanoparticles with 1,3-ß-glucan Enhances the Intracellular Pharmacokinetics of Rifampicin in Macrophages. Pharmaceutical Research, vol. 35: doi: 10.1007/s11095-018-2391-8 | en_US |
| dc.identifier.issn | 1573-904X | |
| dc.identifier.issn | 0724-8741 | |
| dc.identifier.uri | https://link.springer.com/article/10.1007/s11095-018-2391-8 | |
| dc.identifier.uri | https://doi.org/10.1007/s11095-018-2391-8 | |
| dc.identifier.uri | http://hdl.handle.net/10204/10384 | |
| dc.description | Copyright: 2018 Springer. Due to copyright restrictions, the attached PDF file only contains the abstract of the full text item. For access to the full text item, please consult the publisher's website. The published article can be accessed via: https://doi.org/10.1007/s11095-018-2391-8 | en_US |
| dc.description.abstract | Mycobacterium tuberculosis which causes tuberculosis, is primarily resident within macrophages. 1,3-ß-glucan has been proposed as a ligand to target drug loaded nanoparticles (NPs) to macrophages. In this study we characterized the intracellular pharmacokinetics of the anti-tubercular drug rifampicin delivered by 1,3-ß-glucan functionalized PLGA NPs (Glu-PLGA). We hypothesized that Glu-PLGA NPs would be taken up at a faster rate than PLGA NPs, and consequently deliver higher amounts of rifampicin into the macrophages. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Springer | en_US |
| dc.relation.ispartofseries | Worklist;21245 | |
| dc.subject | 1,3-ß-glucan | en_US |
| dc.subject | nanoparticle drug delivery | en_US |
| dc.subject | pharmacokinetic modelling | en_US |
| dc.subject | PLGA nanoparticles | en_US |
| dc.subject | rifampicin intracellular concentrations | en_US |
| dc.title | Functionalization of PLGA Nanoparticles with 1,3-ß-glucan Enhances the Intracellular Pharmacokinetics of Rifampicin in Macrophages | en_US |
| dc.type | Article | en_US |
| dc.identifier.apacitation | Tukulula, M., Gouveia, L., Paixao, P., Hayeshi, R., Naicker, B., & Dube, A. (2018). Functionalization of PLGA Nanoparticles with 1,3-ß-glucan Enhances the Intracellular Pharmacokinetics of Rifampicin in Macrophages. http://hdl.handle.net/10204/10384 | en_ZA |
| dc.identifier.chicagocitation | Tukulula, M, L Gouveia, P Paixao, R Hayeshi, Brendon Naicker, and A Dube "Functionalization of PLGA Nanoparticles with 1,3-ß-glucan Enhances the Intracellular Pharmacokinetics of Rifampicin in Macrophages." (2018) http://hdl.handle.net/10204/10384 | en_ZA |
| dc.identifier.vancouvercitation | Tukulula M, Gouveia L, Paixao P, Hayeshi R, Naicker B, Dube A. Functionalization of PLGA Nanoparticles with 1,3-ß-glucan Enhances the Intracellular Pharmacokinetics of Rifampicin in Macrophages. 2018; http://hdl.handle.net/10204/10384. | en_ZA |
| dc.identifier.ris | TY - Article AU - Tukulula, M AU - Gouveia, L AU - Paixao, P AU - Hayeshi, R AU - Naicker, Brendon AU - Dube, A AB - Mycobacterium tuberculosis which causes tuberculosis, is primarily resident within macrophages. 1,3-ß-glucan has been proposed as a ligand to target drug loaded nanoparticles (NPs) to macrophages. In this study we characterized the intracellular pharmacokinetics of the anti-tubercular drug rifampicin delivered by 1,3-ß-glucan functionalized PLGA NPs (Glu-PLGA). We hypothesized that Glu-PLGA NPs would be taken up at a faster rate than PLGA NPs, and consequently deliver higher amounts of rifampicin into the macrophages. DA - 2018-06 DB - ResearchSpace DP - CSIR KW - 1,3-ß-glucan KW - nanoparticle drug delivery KW - pharmacokinetic modelling KW - PLGA nanoparticles KW - rifampicin intracellular concentrations LK - https://researchspace.csir.co.za PY - 2018 SM - 1573-904X SM - 0724-8741 T1 - Functionalization of PLGA Nanoparticles with 1,3-ß-glucan Enhances the Intracellular Pharmacokinetics of Rifampicin in Macrophages TI - Functionalization of PLGA Nanoparticles with 1,3-ß-glucan Enhances the Intracellular Pharmacokinetics of Rifampicin in Macrophages UR - http://hdl.handle.net/10204/10384 ER - | en_ZA |
