Mycobacterium tuberculosis which causes tuberculosis, is primarily resident within macrophages. 1,3-ß-glucan has been proposed as a ligand to target drug loaded nanoparticles (NPs) to macrophages. In this study we characterized the intracellular pharmacokinetics of the anti-tubercular drug rifampicin delivered by 1,3-ß-glucan functionalized PLGA NPs (Glu-PLGA). We hypothesized that Glu-PLGA NPs would be taken up at a faster rate than PLGA NPs, and consequently deliver higher amounts of rifampicin into the macrophages.
Reference:
Tukulula, M. et al. 2018. Functionalization of PLGA Nanoparticles with 1,3-ß-glucan Enhances the Intracellular Pharmacokinetics of Rifampicin in Macrophages. Pharmaceutical Research, vol. 35: doi: 10.1007/s11095-018-2391-8
Tukulula, M., Gouveia, L., Paixao, P., Hayeshi, R., Naicker, B., & Dube, A. (2018). Functionalization of PLGA Nanoparticles with 1,3-ß-glucan Enhances the Intracellular Pharmacokinetics of Rifampicin in Macrophages. http://hdl.handle.net/10204/10384
Tukulula, M, L Gouveia, P Paixao, R Hayeshi, Brendon Naicker, and A Dube "Functionalization of PLGA Nanoparticles with 1,3-ß-glucan Enhances the Intracellular Pharmacokinetics of Rifampicin in Macrophages." (2018) http://hdl.handle.net/10204/10384
Tukulula M, Gouveia L, Paixao P, Hayeshi R, Naicker B, Dube A. Functionalization of PLGA Nanoparticles with 1,3-ß-glucan Enhances the Intracellular Pharmacokinetics of Rifampicin in Macrophages. 2018; http://hdl.handle.net/10204/10384.
Copyright: 2018 Springer. Due to copyright restrictions, the attached PDF file only contains the abstract of the full text item. For access to the full text item, please consult the publisher's website. The published article can be accessed via: https://doi.org/10.1007/s11095-018-2391-8
ResearchSpace
