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Browsing by Author "Alexandre, Kabamba B"

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Binding of the mannose-specific lectin, griffithsin, to HIV-1 gp120 exposes the CD4-binding site

Author: Alexandre, Kabamba B ; Gray, ES ; Pantophlet, R ; Moore, PL ; McMahon, JB ; Chakauya, E ; O'Keefe, BR ; Chikwamba, Rachel K ; Morris, L Date: Sep 2011 The glycans on HIV-1 gp120 play an important role in shielding neutralization sensitive epitopes from antibody recognition. They also serve as targets for lectins that bind mannose-rich glycans. In this study we investigated the interaction ... Read more
Binding of the mannose-specific lectin, Griffithsin, to HIV-1 gp120 exposes the CD4-binding site

Author: Alexandre, Kabamba B ; Gray, ES ; Pantophlet, R ; Moore, PL ; McMahon, JB ; Chakauya, E ; O'Keefe, BR ; Chikwamba, Rachel K ; Morris, L Date: Sep 2011 The glycans on HIV-1 gp120 play an important role in shielding neutralization-sensitive epitopes from antibody recognition. They also serve as targets for lectins that bind mannose-rich glycans. In this study, the authors investigated the ... Read more
HIV-1 subtype C primary isolates exhibit high sensitivity to an anti-gp120 RNA aptamer

Author: Mufhandu, Hazel T ; Alexandre, Kabamba B ; Gray, ES ; Morris, L ; Khati, M Date: Sep 2012 Globally, HIV-1 subtype C is the most prevalent subtype, yet most antiretroviral drugs are developed against subtype B. UCLA1 RNA aptamer, which we previously showed neutralizes HIV-1 subtype C Env-pseudotyped viruses was examined for ... Read more
In vitro study on efficacy of PHELA, an African traditional drug against SARS-CoV-2

Author: Matsabisa, MG ; Alexandre, Kabamba B ; Ibeji, CU ; Tripathy, S ; Erukainure, OL ; Malatji, Kanyane ; Chauke, Sipho H ; Okole, Blessed N ; Chabalal, HB Date: Jun 2022 In 2019, coronavirus has made the third apparition in the form of SARS-CoV-2, a novel strain of coronavirus that is extremely pathogenic and it uses the same receptor as SARS-CoV, the angiotensin converting enzyme 2 (ACE2). However, more than ... Read more
The lectins griffithsin, cyanovirin-N and scytovirin inhibit HIV-1 binding to the DC-SIGN receptor and transfer to CD4+ cells

Author: Alexandre, Kabamba B ; Gray, ES ; Mufhandu, Hazel T ; McMahon, JB ; Chakauya, E ; O'Keefe, BR ; Chikwamba, Rachel K ; Morris, L Date: Feb 2012 It is generally believed that during the sexual transmission of HIV-1, the glycan-specific DC-SIGN receptor binds the virus and mediates its transfer to CD4(+) cells. The lectins griffithsin (GRFT), cyanovirin-N (CV-N) and scytovirin (SVN) ... Read more
Mechanisms of HIV-1 subtype C resistance to GRFT, CV-N and SVN

Author: Alexandre, Kabamba B ; Moore, PL ; Nonyane, M ; Gray, ES ; Ranchobe, N ; Chakauya, E ; McMahon, JB ; O'Keefe, BR ; Chikwamba, Rachel K ; Morris, L Date: Nov 2013 We examined the ability of HIV-1 subtype C to develop resistance to the inhibitory lectins, griffithsin (GRFT), cyanovirin-N (CV-N) and scytovirin (SVN), which bind multiple mannose-rich glycans on gp120. Four primary HIV-1 strains cultured ... Read more
Progress and perspectives on HIV-1 microbicide development

Author: Alexandre, Kabamba B ; Mufhandu, Hazel T ; London, GM ; Chakauya, E ; Khati, M Date: Oct 2016 The majority of HIV-1 infections occur via sexual intercourse. Women are the most affected by the epidemic, particularly in developing countries, due to their socio-economic dependence on men and the fact that they are often victims of gender ... Read more
Synthesis of 2-substituted tetrahydroisoquinolin-6-ols: Potential scaffolds for estrogen receptor modulation and/or microtubule degradation

Author: Mabank, T ; Alexandre, Kabamba B ; Pelly, SC ; Green, IR ; Van Otterlo, WAL Date: Jul 2019 6-Methoxytetrahydroisoquinoline hydrochloride was converted into four small libraries of substituted ureas, thioureas, sulfonamides and N-aryls, using the tetrahydroisoquinoline nitrogen as the scaffold-linking atom. Some of the compounds ... Read more
Transient proteolysis reduction of Nicotiana benthamiana-produced CAP256 broadly neutralizing antibodies using CRISPR/Cas9

Author: Singh, Advaita A ; Pillay, Priyen ; Naicker, Previn ; Alexandre, Kabamba B ; Malatji, Kanyane ; Mach, L ; Steinkellner, H ; Vorster, J ; Chikwamba, Rachel K ; Tsekoa, Tsepo L Date: Aug 2022 The hypersensitive response is elicited by Agrobacterium infiltration of Nicotiana benthamiana, including the induction and accumulation of pathogenesis-related proteins, such as proteases. This includes the induction of the expression of ... Read more
UCLA1 aptamer inhibition of human immunodeficiency virus type 1 subtype C primary isolates in macrophages and selection of resistance

Author: Mufhandu, Hazel T ; Alexandre, Kabamba B ; Gray, ES ; Morris, L ; Khati, M Date: Sep 2016 We have previously shown that the aptamer, UCLA1, is able to inhibit HIV-1 replication in peripheral blood mononuclear cells (PBMCs) by binding to residues in gp120. In this study we examined whether UCLA1 was effective against HIV-1 subtype ... Read more
UCLA1, a synthetic derivative of a gp120 RNA aptamer, inhibits entry of human immunodeficiency virus type 1 subtype C

Author: Mufhandu, Hazel T ; Gray, ES ; Madiga, MC ; Tumba, N ; Alexandre, Kabamba B ; Khoza, T ; Wibmer, CK ; Moore, PL ; Morris, L ; Khati, M Date: May 2012 Entry of human immunodeficiency virus type 1 (HIV-1) into cells is mediated by the virion surface envelope (Env) glycoproteins, making it a desirable target for antiretroviral entry inhibitors. We previously isolated a family of gp120 binding ... Read more

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Browsing by Author "Alexandre, Kabamba B"

Browsing by Author "Alexandre, Kabamba B"

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