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Browsing by Subject "PLGA nanoparticles"

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Curdlan-conjugated PLGA nanoparticles possess macrophage stimulant activity and drug delivery capabilities

Author: Tukulula, M ; Hayeshi, R ; Fonteh, P ; Meyer, D ; Ndamase, A ; Madziva, MT ; Khumalo, V ; Lubuschagne, P ; Naicker, B ; Swai, H ; Dube, A Date: Feb 2015 There is significant interest in the application of nanoparticles to deliver immunostimulatory signals to cells. We hypothesized that curdlan (immune stimulating polymer) could be conjugated to PLGA and nanoparticles from this copolymer would ... Read more
Functionalization of PLGA Nanoparticles with 1,3-ß-glucan Enhances the Intracellular Pharmacokinetics of Rifampicin in Macrophages

Author: Tukulula, M ; Gouveia, L ; Paixao, P ; Hayeshi, R ; Naicker, Brendon ; Dube, A Date: Jun 2018 Mycobacterium tuberculosis which causes tuberculosis, is primarily resident within macrophages. 1,3-ß-glucan has been proposed as a ligand to target drug loaded nanoparticles (NPs) to macrophages. In this study we characterized the intracellular ... Read more
In vitro characterisation of PLGA nanoparticles encapsulating rifampicin and isoniazid - Towards IVIVC

Author: Booysen, L ; Semete-Makokotlela, Boitumelo ; Kalombo, Lonji ; Swai, H ; Kotzé, AF Date: 01 Sep 2010 It has been postulated that antituberculosis drugs encapsulated in polymeric nanoparticles are able to control the release of these drugs in vivo. These biodegradable polymers facilitate sustained/controlled release by means of degradation ... Read more
In vivo/in vitro pharmacokinetic and pharmacodynamic study of spray-dried poly-(dl-lactic-co-glycolic) acid nanoparticles encapsulating rifampicin and isoniazid

Author: Booysen, LLIJ ; Kalombo, Lonji ; Brooks, E ; Hansen, R ; Gilliland, J ; Gruppo, V ; Lungenhofer, P ; Semete-Makokotlela, Boitumelo ; Swai, HS ; Kotze, AF ; Lenaerts, A ; du Plessis, LH Date: Feb 2013 Poly-(dl-lactic-co-glycolic) acid (PLGA) nanoparticles were prepared by a double emulsion solvent evaporation spray-drying technique and coated with polyethylene glycol (PEG 1% v/v). The PLGA nanoparticles had a small size (229±7.6 to ... Read more
Potential of improving the treatment of tuberculosis through nanomedicine

Author: Semete, B ; Kalombo, Lonji ; Katata, L ; Chelule, P ; Booysen, L ; Lemmer, Yolandy ; Naidoo, Saloshnee ; Ramalapa, B ; Hayeshi, R ; Swai, HS Date: Mar 2012 Current treatment of tuberculosis is inadequate due to lengthy treatment course and drug-related toxicity. To address these setbacks, we developed a nanotechnology drug delivery system that can be administered in a single dose that maintains ... Read more

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Browsing by Subject "PLGA nanoparticles"

Browsing by Subject "PLGA nanoparticles"

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