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Browsing by Subject "Isoniazid"

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Computer-aided construction and investigation of a thermodynamically stable mouth-dissolving film containing isoniazid

Author: Adeleke, Oluwatoyin A ; Karry, KM ; Michniak-Kohn, BB ; Monama, Nkwe O Date: Oct 2015 The purpose of this abstract is to design and characterize a thermodynamically stable mouth-dissolving film containing isoniazid employing in silico and in vitro techniques. Isoniazid (solubility = 140 mg/mL and log P = -0.64 at 25°C) is a ... Read more
In vitro characterisation of PLGA nanoparticles encapsulating rifampicin and isoniazid - Towards IVIVC

Author: Booysen, L ; Semete-Makokotlela, Boitumelo ; Kalombo, Lonji ; Swai, H ; Kotzé, AF Date: 01 Sep 2010 It has been postulated that antituberculosis drugs encapsulated in polymeric nanoparticles are able to control the release of these drugs in vivo. These biodegradable polymers facilitate sustained/controlled release by means of degradation ... Read more
In vivo/in vitro pharmacokinetic and pharmacodynamic study of spray-dried poly-(dl-lactic-co-glycolic) acid nanoparticles encapsulating rifampicin and isoniazid

Author: Booysen, LLIJ ; Kalombo, Lonji ; Brooks, E ; Hansen, R ; Gilliland, J ; Gruppo, V ; Lungenhofer, P ; Semete-Makokotlela, Boitumelo ; Swai, HS ; Kotze, AF ; Lenaerts, A ; du Plessis, LH Date: Feb 2013 Poly-(dl-lactic-co-glycolic) acid (PLGA) nanoparticles were prepared by a double emulsion solvent evaporation spray-drying technique and coated with polyethylene glycol (PEG 1% v/v). The PLGA nanoparticles had a small size (229±7.6 to ... Read more
Isoniazid-loaded orodispersible strips: Methodical design, optimization and in vitro-in silico characterization

Author: Adeleke, Oluwatoyin A ; Tsai, P ; Karry, KM ; Monama, Nkwe O ; Michniak-Kohn, BB Date: Aug 2021 Drug treatment remains the most effective global approach to managing and preventing tuberculosis. This work focuses on formulating and evaluating an optimized polyvinyl alcohol-polyethylene glycol based orodispersible strip containing ... Read more

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Browsing by Subject "Isoniazid"

Browsing by Subject "Isoniazid"

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