Drug treatment remains the most effective global approach to managing and preventing tuberculosis. This work focuses on formulating and evaluating an optimized polyvinyl alcohol-polyethylene glycol based orodispersible strip containing isoniazid, a first-line anti-tubercular agent. A solvent casting method guided through a Taguchi experimental design was employed in the fabrication, optimization and characterization of the orodispersible strip. The optimized strip was physically amalgamated with a monolayer, uniformly distributed surface geometry. It was 159.2 ± 3.0 µm thick, weighed 36.9 ± 0.3 mg, had an isoniazid load of 99.5 ± 0.8%w/w, disintegration and dissolution times of 17.6 ± 0.9 s and 5.5 ± 0.1 min respectively. In vitro crystallinity, thermal measurements and in silico thermodynamic predictions confirmed the strip's intrinsic miscibility, thermodynamic stability and amorphous nature. A Korsmeyer-Peppas (r = 0.99; n > 1 = 1.07) fitted kinetics typified by an initial burst release of 49.4 ± 1.9% at 4 min and a total of 99.8 ± 3.3% at 30 min was noted. Ex vivo isoniazid permeation through porcine buccal mucosa was bi-phasic and characterized by a 50.4 ± 3.8% surge and 95.6 ± 2.9% at 5 and 120 min respectively. The strip was physicomechanically robust, environmentally stable and non-cytotoxic.
Reference:
Adeleke, O.A., Tsai, P., Karry, K., Monama, N.O. & Michniak-Kohn, B. 2021. Isoniazid-loaded orodispersible strips: Methodical design, optimization and in vitro-in silico characterization. International Journal of Pharmaceutics, 25. http://hdl.handle.net/10204/12176
Adeleke, O. A., Tsai, P., Karry, K., Monama, N. O., & Michniak-Kohn, B. (2021). Isoniazid-loaded orodispersible strips: Methodical design, optimization and in vitro-in silico characterization. International Journal of Pharmaceutics, 25, http://hdl.handle.net/10204/12176
Adeleke, Oluwatoyin A, P Tsai, KM Karry, Nkwe O Monama, and BB Michniak-Kohn "Isoniazid-loaded orodispersible strips: Methodical design, optimization and in vitro-in silico characterization." International Journal of Pharmaceutics, 25 (2021) http://hdl.handle.net/10204/12176
Adeleke OA, Tsai P, Karry K, Monama NO, Michniak-Kohn B. Isoniazid-loaded orodispersible strips: Methodical design, optimization and in vitro-in silico characterization. International Journal of Pharmaceutics, 25. 2021; http://hdl.handle.net/10204/12176.