The purpose of this abstract is to design and characterize a thermodynamically stable mouth-dissolving film containing isoniazid employing in silico and in vitro techniques. Isoniazid (solubility = 140 mg/mL and log P = -0.64 at 25°C) is a first-line antibiotic indicated for the prevention (as a single entity) and treatment (in combination with other medicines) of active tuberculosis infection.
Reference:
Adeleke, O.A., Karry, K.M., Michniak-Kohn, B.B. and Monama, N.O. 2015. Computer-aided construction and investigation of a thermodynamically stable mouth-dissolving film containing isoniazid. In: American Association of Pharmaceutical Scientists Annual Meeting and Exposition, Orlando, United States of America, October 25-29, 2015
Adeleke, O. A., Karry, K., Michniak-Kohn, B., & Monama, N. O. (2015). Computer-aided construction and investigation of a thermodynamically stable mouth-dissolving film containing isoniazid. http://hdl.handle.net/10204/9750
Adeleke, Oluwatoyin A, KM Karry, BB Michniak-Kohn, and Nkwe O Monama. "Computer-aided construction and investigation of a thermodynamically stable mouth-dissolving film containing isoniazid." (2015): http://hdl.handle.net/10204/9750
Adeleke OA, Karry K, Michniak-Kohn B, Monama NO, Computer-aided construction and investigation of a thermodynamically stable mouth-dissolving film containing isoniazid; 2015. http://hdl.handle.net/10204/9750 .
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