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dc.contributor.author Magagula, L
dc.contributor.author Gagliardi, M
dc.contributor.author Naidoo, Jerolen
dc.contributor.author Mhlanga, Musa
dc.date.accessioned 2017-11-20T12:51:02Z
dc.date.available 2017-11-20T12:51:02Z
dc.date.issued 2017-08
dc.identifier.citation Magagula, L. et al. 2017. Lnc-ing inflammation to disease. Biochemical Society Transactions, vol. 45(4): 953-962 en_US
dc.identifier.issn 0300-5127
dc.identifier.uri Doi: 10.1042/BST20160377
dc.identifier.uri http://www.biochemsoctrans.org/content/early/2017/07/05/BST20160377.full
dc.identifier.uri http://hdl.handle.net/10204/9798
dc.description © 2017 The Authors. Article published in Biochemical Society Transactions, vol. 45(4): 953-962 en_US
dc.description.abstract Termed 'master gene regulators' long ncRNAs (lncRNAs) have emerged as the true vanguard of the 'noncoding revolution'. Functioning at a molecular level, in most if not all cellular processes, lncRNAs exert their effects systemically. Thus, it is not surprising that lncRNAs have emerged as important players in human pathophysiology. As our body's first line of defense upon infection or injury, inflammation has been implicated in the etiology of several human diseases. At the center of the acute inflammatory response, as well as several pathologies, is the pleiotropic transcription factor NF- ß. In this review, we attempt to capture a summary of lncRNAs directly involved in regulating innate immunity at various arms of the NF- ß pathway that have also been validated in human disease. We also highlight the fundamental concepts required as lncRNAs enter a new era of diagnostic and therapeutic significance. en_US
dc.language.iso en en_US
dc.publisher Portland Press LTD en_US
dc.relation.ispartofseries Worklist;19820
dc.subject Biomarkers en_US
dc.subject Disease en_US
dc.subject Gene expression en_US
dc.subject Inflammation en_US
dc.subject lncRNA en_US
dc.subject Transcriptional regulation en_US
dc.title Lnc-ing inflammation to disease en_US
dc.type Article en_US


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