dc.contributor.author | Mosangi, Damodar | |
dc.contributor.author | Moyo, Lumbidzani | |
dc.contributor.author | Kesavan Pillai, Sreejarani | |
dc.contributor.author | Ray, Suprakas S | |
dc.date.accessioned | 2017-05-16T10:30:39Z | |
dc.date.available | 2017-05-16T10:30:39Z | |
dc.date.issued | 2016-10 | |
dc.identifier.citation | Mosangi, D., Moyo, L., Kesavan Pillai, S. et al. 2016. Acetyl salicylic acid–ZnAl layered double hydroxide functional nanohybrid for skin care application. RSC Advances, vol. 107(6): 105862-105870 | en_US |
dc.identifier.issn | 2046-2069 | |
dc.identifier.uri | http://pubs.rsc.org/en/content/articlelanding/2016/ra/c6ra22172f#!divAbstract | |
dc.identifier.uri | DOI: 10.1039/C6RA22172F | |
dc.identifier.uri | http://hdl.handle.net/10204/9046 | |
dc.description | © The Royal Society of Chemistry 2016 | en_US |
dc.description.abstract | In this study, a pharmaceutically active ingredient, acetyl salicylic acid (ASA), was intercalated into ZnAl layered double hydroxide (LDH). The LDH–ASA nanohybrid material was characterized by XRD, FTIR, SEM, ICP-MS, TEM and TGA. Successful incorporation of ASA into LDH interlayers through electrostatic interactions was confirmed by FTIR results. ASA in the intercalated form showed higher thermal stability in comparison to pure ASA. In vitro release studies revealed that the nanohybrid in release media (artificial sweat/phosphate-buffered saline) could effectively facilitate the ASA diffusion by significantly increasing the release time. The nanohybrid was also used to develop a topical skin care formulation, and skin permeation kinetic studies were conducted by a Franz diffusion cell using reconstructed skin samples. The results from the Franz diffusion cell experiments showed that the formulation with the LDH–ASA nanohybrid drastically increased the penetration rate for ASA compared to the formulation with pure ASA. From these studies, we can conclude that the in situ intercalation of an LDH–ASA nanohybrid system is a promising alternative active ingredient for topical cosmetic emulsions. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Royal Society of Chemistry | en_US |
dc.rights | CC0 1.0 Universal | * |
dc.rights.uri | http://creativecommons.org/publicdomain/zero/1.0/ | * |
dc.subject | Acetyl salicylic acid | en_US |
dc.subject | ASA | en_US |
dc.subject | Topical skin formulations | en_US |
dc.title | Acetyl salicylic acid–ZnAl layered double hydroxide functional nanohybrid for skin care application | en_US |
dc.type | Article | en_US |
dc.identifier.apacitation | Mosangi, D., Moyo, L., Kesavan Pillai, S., & Ray, S. S. (2016). Acetyl salicylic acid–ZnAl layered double hydroxide functional nanohybrid for skin care application. http://hdl.handle.net/10204/9046 | en_ZA |
dc.identifier.chicagocitation | Mosangi, Damodar, Lumbidzani Moyo, Sreejarani Kesavan Pillai, and Suprakas S Ray "Acetyl salicylic acid–ZnAl layered double hydroxide functional nanohybrid for skin care application." (2016) http://hdl.handle.net/10204/9046 | en_ZA |
dc.identifier.vancouvercitation | Mosangi D, Moyo L, Kesavan Pillai S, Ray SS. Acetyl salicylic acid–ZnAl layered double hydroxide functional nanohybrid for skin care application. 2016; http://hdl.handle.net/10204/9046. | en_ZA |
dc.identifier.ris | TY - Article AU - Mosangi, Damodar AU - Moyo, Lumbidzani AU - Kesavan Pillai, Sreejarani AU - Ray, Suprakas S AB - In this study, a pharmaceutically active ingredient, acetyl salicylic acid (ASA), was intercalated into ZnAl layered double hydroxide (LDH). The LDH–ASA nanohybrid material was characterized by XRD, FTIR, SEM, ICP-MS, TEM and TGA. Successful incorporation of ASA into LDH interlayers through electrostatic interactions was confirmed by FTIR results. ASA in the intercalated form showed higher thermal stability in comparison to pure ASA. In vitro release studies revealed that the nanohybrid in release media (artificial sweat/phosphate-buffered saline) could effectively facilitate the ASA diffusion by significantly increasing the release time. The nanohybrid was also used to develop a topical skin care formulation, and skin permeation kinetic studies were conducted by a Franz diffusion cell using reconstructed skin samples. The results from the Franz diffusion cell experiments showed that the formulation with the LDH–ASA nanohybrid drastically increased the penetration rate for ASA compared to the formulation with pure ASA. From these studies, we can conclude that the in situ intercalation of an LDH–ASA nanohybrid system is a promising alternative active ingredient for topical cosmetic emulsions. DA - 2016-10 DB - ResearchSpace DP - CSIR KW - Acetyl salicylic acid KW - ASA KW - Topical skin formulations LK - https://researchspace.csir.co.za PY - 2016 SM - 2046-2069 T1 - Acetyl salicylic acid–ZnAl layered double hydroxide functional nanohybrid for skin care application TI - Acetyl salicylic acid–ZnAl layered double hydroxide functional nanohybrid for skin care application UR - http://hdl.handle.net/10204/9046 ER - | en_ZA |
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