In this research, aminoquinoline compounds were synthesized, characterized and incorporated into water soluble polymers to form conjugates. The conjugates were characterized by X ray Diffraction (XRD), Thermal Gravimetric Analysis (TGA), Scanning Electron Microscope (SEM), Fourier Transform Spectroscopy (FTIR) and Nuclear Magnetic Resonance spectroscopy (NMR) to confirm the successful incorporation of the aminoquinoline compound on to the polymer. The synthesized conjugates were screened for in vitro antiplasmodial activity in triplet test against chloroquine sensitive strain of Plasmodium falciparum and chloroquine drug was used as a reference drug in all the experiments. A full dose response was performed to determine the concentration inhibiting 50% of parasite growth (IC(sub50)-value). Polymeric conjugates containing 3-diethylamino-1-propylamine solubilizing units were found to be most active against the chloroquine sensitive strain of Plasmodium falciparum.
Reference:
Aderibigbe, B.A, Neuse, E.W, Sadiku, E.R, Shina Ray, S and Smith, P.J. 2014. Synthesis, characterization, and antiplasmodial activity of polymer-incorporated aminoquinolines. Journal of Biomedical Materials Research Part A, vol. 102(A), pp 1941-1949
Aderibigbe, B., Neuse, E., Sadiku, E., Shina Ray, S., & Smith, P. (2014). Synthesis, characterization, and antiplasmodial activity of polymer-incorporated aminoquinolines. http://hdl.handle.net/10204/7701
Aderibigbe, BA, EW Neuse, ER Sadiku, S Shina Ray, and PJ Smith "Synthesis, characterization, and antiplasmodial activity of polymer-incorporated aminoquinolines." (2014) http://hdl.handle.net/10204/7701
Aderibigbe B, Neuse E, Sadiku E, Shina Ray S, Smith P. Synthesis, characterization, and antiplasmodial activity of polymer-incorporated aminoquinolines. 2014; http://hdl.handle.net/10204/7701.
Copyright: 2014 Wiley. This is an ABSTRACT ONLY. The definitive version is published in Journal of Biomedical Materials Research Part A, vol. 102(A), pp 1941-1949
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