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Antileishmanial activity of 12-methoxycarnosic acid from Salvia repens Burch. ex Benth. (Lamiaceae)

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dc.contributor.author Mokoka, TA
dc.contributor.author Peter, Xolani K
dc.contributor.author Fouché, Gerda
dc.contributor.author Moodley, N
dc.contributor.author Adams, M
dc.contributor.author Hamburger, M
dc.contributor.author Kaiser, M
dc.contributor.author Brun, R
dc.contributor.author Maharaj, V
dc.contributor.author Koorbanally, Nicoli A
dc.date.accessioned 2014-04-10T13:24:49Z
dc.date.available 2014-04-10T13:24:49Z
dc.date.issued 2014-01
dc.identifier.citation Mokoka, T.A, Peter, X.K, Fouche, G, Moodley, N, Adams, M, Hamburger, M, Kaiser, M, Brun, R, Maharaj, V and Koorbanally, N. 2014. Antileishmanial activity of 12-methoxycarnosic acid from Salvia repens Burch. ex Benth. (Lamiaceae). South African Journal of Botany, vol. 90, pp 93-95 en_US
dc.identifier.issn 0254-6299
dc.identifier.uri http://ac.els-cdn.com/S0254629913004158/1-s2.0-S0254629913004158-main.pdf?_tid=1ed1cb5c-b34a-11e3-984b-00000aab0f01&acdnat=1395661847_f385a3a820505feff7f8d3c13f65ab48
dc.identifier.uri http://hdl.handle.net/10204/7354
dc.identifier.uri https://www.sciencedirect.com/science/article/pii/S0254629913004158
dc.identifier.uri https://doi.org/10.1016/j.sajb.2013.10.014
dc.description Copyright: 2014 Elsevier. This is the pre-print version. The definitive version is published in South African Journal of Botany, vol. 90, pp 93-95 en_US
dc.description.abstract In South Africa, Salvia repens is used traditionally to treat sores, stomach ache and diarrhoea. The high performance liquid chromatography (HPLC)-based activity profiling of S. repens whole plant extract showed an active abietane diterpene, identified as 12-methoxycarnosic acid (1) which showed antiprotozoal activity against axenically grown Leishmania donovani amastigotes with an IC(sub50) of 0.75 µM with marginal cytotoxicity against the L6-cells (IC(sub50), 17.3 µM). en_US
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries Workflow;12198
dc.subject Antileishmanial activity en_US
dc.subject Salvia repens en_US
dc.subject Leishmania donovani en_US
dc.subject 12-Methoxycarnosic acid en_US
dc.subject Abietane diterpene en_US
dc.subject HPLC profiling en_US
dc.title Antileishmanial activity of 12-methoxycarnosic acid from Salvia repens Burch. ex Benth. (Lamiaceae) en_US
dc.type Article en_US
dc.identifier.apacitation Mokoka, T., Peter, X. K., Fouché, G., Moodley, N., Adams, M., Hamburger, M., ... Koorbanally, N. A. (2014). Antileishmanial activity of 12-methoxycarnosic acid from Salvia repens Burch. ex Benth. (Lamiaceae). http://hdl.handle.net/10204/7354 en_ZA
dc.identifier.chicagocitation Mokoka, TA, Xolani K Peter, Gerda Fouché, N Moodley, M Adams, M Hamburger, M Kaiser, R Brun, V Maharaj, and Nicoli A Koorbanally "Antileishmanial activity of 12-methoxycarnosic acid from Salvia repens Burch. ex Benth. (Lamiaceae)." (2014) http://hdl.handle.net/10204/7354 en_ZA
dc.identifier.vancouvercitation Mokoka T, Peter XK, Fouché G, Moodley N, Adams M, Hamburger M, et al. Antileishmanial activity of 12-methoxycarnosic acid from Salvia repens Burch. ex Benth. (Lamiaceae). 2014; http://hdl.handle.net/10204/7354. en_ZA
dc.identifier.ris TY - Article AU - Mokoka, TA AU - Peter, Xolani K AU - Fouché, Gerda AU - Moodley, N AU - Adams, M AU - Hamburger, M AU - Kaiser, M AU - Brun, R AU - Maharaj, V AU - Koorbanally, Nicoli A AB - In South Africa, Salvia repens is used traditionally to treat sores, stomach ache and diarrhoea. The high performance liquid chromatography (HPLC)-based activity profiling of S. repens whole plant extract showed an active abietane diterpene, identified as 12-methoxycarnosic acid (1) which showed antiprotozoal activity against axenically grown Leishmania donovani amastigotes with an IC(sub50) of 0.75 µM with marginal cytotoxicity against the L6-cells (IC(sub50), 17.3 µM). DA - 2014-01 DB - ResearchSpace DP - CSIR KW - Antileishmanial activity KW - Salvia repens KW - Leishmania donovani KW - 12-Methoxycarnosic acid KW - Abietane diterpene KW - HPLC profiling LK - https://researchspace.csir.co.za PY - 2014 SM - 0254-6299 T1 - Antileishmanial activity of 12-methoxycarnosic acid from Salvia repens Burch. ex Benth. (Lamiaceae) TI - Antileishmanial activity of 12-methoxycarnosic acid from Salvia repens Burch. ex Benth. (Lamiaceae) UR - http://hdl.handle.net/10204/7354 ER - en_ZA


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