dc.contributor.author |
Hata, Y
|
|
dc.contributor.author |
Raith, M
|
|
dc.contributor.author |
Ebrahimi, SN
|
|
dc.contributor.author |
Zimmermann, S
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|
dc.contributor.author |
Mokoka, T
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|
dc.contributor.author |
Naidoo, Dashnie
|
|
dc.contributor.author |
Fouché, Gerda
|
|
dc.contributor.author |
Maharaj, V
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|
dc.contributor.author |
Kaiser, M
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|
dc.contributor.author |
Brun, R
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|
dc.contributor.author |
Hamburger, M
|
|
dc.date.accessioned |
2013-09-05T07:51:36Z |
|
dc.date.available |
2013-09-05T07:51:36Z |
|
dc.date.issued |
2013-04 |
|
dc.identifier.citation |
Hata, Y, Raith, M, Ebrahimi, S.N, Zimmermann, S, Mokoka, T, Naidoo, D, Fouche, G, Maharaj, V, Kaiser, M, Brun, R and Hamburger, M. 2013. Antiprotozoal Isoflavan Quinones from Abrus precatorius ssp. africanus. Planta Medica, vol. 79(6), pp 492-498 |
en_US |
dc.identifier.issn |
0032-0943 |
|
dc.identifier.uri |
https://www.thieme-connect.com/ejournals/abstract/10.1055/s-0032-1321293
|
|
dc.identifier.uri |
http://hdl.handle.net/10204/6960
|
|
dc.description |
Copyright: 2013 Georg Thieme Verlag. This is an ABSTRACT ONLY. The definitive version is published in Planta Medica, vol. 79(6), pp 492-498 |
en_US |
dc.description.abstract |
A library of 206 extracts from selected South African plants was screened in vitro against a panel of protozoan parasites, Plasmodium falciparum, Trypanosoma brucei rhodesiense, and Leishmania donovani. A CH(sub)2Cl(sub)2/MeOH (1:1) extract of Abrus precatorius L. ssp. africanus strongly inhibited P.falciparum (98%), T. b. rhodesiense (100%), and L. donovani (76%) when tested at a concentration of 10.0 μg/mL. The active constituents were tracked by HPLC-based activity profiling and isolated by preparative and semipreparative RPHPLC chromatography. Structures were established by HR-ESIMS, and 1D and 2D NMR ((sup)1H, (sup)13C, COSY, HMBC, HSQC, and NOE difference spectroscopy). Five compounds were obtained and identified as two isoflavan hydroquinones, abruquinone H (1) and abruquinone G (2), and three isoflavan quinones, abruquinone I (3), abruquinone B (4), and 7, 8, 3′‚5′- tetramethoxyisoflavan-1′,4′- quinone (5). Compounds 1 and 3 were new natural products. The absolute configuration of compounds was determined by comparison of electronic circular dichroism spectra with calculated ECD data. Compounds 3 and 4 showed strong activity against T. b. rhodesiense (IC(sub)50 values of 0.30 and 0.16 μM, respectively) and good selectivity (selectivity indices of 73.7 and 50.5, respectively). |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Georg Thieme Verlag |
en_US |
dc.relation.ispartofseries |
Workflow;11380 |
|
dc.subject |
Antiprotozoal |
en_US |
dc.subject |
Trypanosoma brucei rhodesiense |
en_US |
dc.subject |
Isoflavan quinone |
en_US |
dc.subject |
Abrus precatorius |
en_US |
dc.subject |
Fabaceae |
en_US |
dc.subject |
Electronic circular dichroism |
en_US |
dc.title |
Antiprotozoal Isoflavan Quinones from Abrus precatorius ssp. africanus |
en_US |
dc.type |
Article |
en_US |
dc.identifier.apacitation |
Hata, Y., Raith, M., Ebrahimi, S., Zimmermann, S., Mokoka, T., Naidoo, D., ... Hamburger, M. (2013). Antiprotozoal Isoflavan Quinones from Abrus precatorius ssp. africanus. http://hdl.handle.net/10204/6960 |
en_ZA |
dc.identifier.chicagocitation |
Hata, Y, M Raith, SN Ebrahimi, S Zimmermann, T Mokoka, Dashnie Naidoo, Gerda Fouché, et al "Antiprotozoal Isoflavan Quinones from Abrus precatorius ssp. africanus." (2013) http://hdl.handle.net/10204/6960 |
en_ZA |
dc.identifier.vancouvercitation |
Hata Y, Raith M, Ebrahimi S, Zimmermann S, Mokoka T, Naidoo D, et al. Antiprotozoal Isoflavan Quinones from Abrus precatorius ssp. africanus. 2013; http://hdl.handle.net/10204/6960. |
en_ZA |
dc.identifier.ris |
TY - Article
AU - Hata, Y
AU - Raith, M
AU - Ebrahimi, SN
AU - Zimmermann, S
AU - Mokoka, T
AU - Naidoo, Dashnie
AU - Fouché, Gerda
AU - Maharaj, V
AU - Kaiser, M
AU - Brun, R
AU - Hamburger, M
AB - A library of 206 extracts from selected South African plants was screened in vitro against a panel of protozoan parasites, Plasmodium falciparum, Trypanosoma brucei rhodesiense, and Leishmania donovani. A CH(sub)2Cl(sub)2/MeOH (1:1) extract of Abrus precatorius L. ssp. africanus strongly inhibited P.falciparum (98%), T. b. rhodesiense (100%), and L. donovani (76%) when tested at a concentration of 10.0 μg/mL. The active constituents were tracked by HPLC-based activity profiling and isolated by preparative and semipreparative RPHPLC chromatography. Structures were established by HR-ESIMS, and 1D and 2D NMR ((sup)1H, (sup)13C, COSY, HMBC, HSQC, and NOE difference spectroscopy). Five compounds were obtained and identified as two isoflavan hydroquinones, abruquinone H (1) and abruquinone G (2), and three isoflavan quinones, abruquinone I (3), abruquinone B (4), and 7, 8, 3′‚5′- tetramethoxyisoflavan-1′,4′- quinone (5). Compounds 1 and 3 were new natural products. The absolute configuration of compounds was determined by comparison of electronic circular dichroism spectra with calculated ECD data. Compounds 3 and 4 showed strong activity against T. b. rhodesiense (IC(sub)50 values of 0.30 and 0.16 μM, respectively) and good selectivity (selectivity indices of 73.7 and 50.5, respectively).
DA - 2013-04
DB - ResearchSpace
DP - CSIR
KW - Antiprotozoal
KW - Trypanosoma brucei rhodesiense
KW - Isoflavan quinone
KW - Abrus precatorius
KW - Fabaceae
KW - Electronic circular dichroism
LK - https://researchspace.csir.co.za
PY - 2013
SM - 0032-0943
T1 - Antiprotozoal Isoflavan Quinones from Abrus precatorius ssp. africanus
TI - Antiprotozoal Isoflavan Quinones from Abrus precatorius ssp. africanus
UR - http://hdl.handle.net/10204/6960
ER -
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en_ZA |