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Please use this identifier to cite or link to this item: http://hdl.handle.net/10204/6354

Title: Ultrastructural analyses of platelets and fibrin networks in BALB/c mice after inhalation of spherical and rod-shaped titanium nanoparticles
Authors: Oosthuizen, MA
Pretorius, E
Oberholzer, HM
Van der Spuy, WJ
Keywords: Nanoparticles
TiO2
Platelets
Fibrin
BALB/c
Environmental management
Pollution and waste
Nanotechnology
Nanotechnology community
Issue Date: Oct-2010
Publisher: Sociedad Chilena de Anatomía
Citation: Oosthuizen, M.A, Pretorius, E, Oberholzer, H.M and Van der Spuy, W.J. 2010. Ultrastructural analyses of platelets and fibrin networks in BALB/c mice after inhalation of spherical and rod-shaped titanium nanoparticles. International Journal of Morphology, Vol. 28(4), pp 1263-1271
Series/Report no.: Workflow;7048
Abstract: Engineered nanoparticles are designed to perform specific functions and therefore have specific properties that could potentially be harmful. Nanoparticles such as titanium dioxide have the potential to become transparent and are therefore widely used in cosmetic products and sunscreen. Research on the toxicity of nanoparticles is of utmost importance and numerous in vitro studies have shown that some of these particles could have adverse health effects. The current study aimed to investigate the in vivo effects of two different titanium nanoparticles at two different concentrations after inhalation by experimental BALB/c mice. This was done to determine whether these particles will cause an inflammatory reaction, visible as alterations in platelet and fibrin ultrastructure. Mice were divided into five experimental groups comprising of a control group, high and low concentration groups exposed to the sphericalshaped particles, as well as high and low concentration groups exposed to the rod-shaped particles. The ultrastructure of the fibrin networks and platelet aggregates of these experimental groups were investigated and compared to that of controls. Results indicated that the fibrin networks of the exposed animals have a net-like covering over the major fibres, typical to that found in animals with inflammation. It can therefore be concluded that the nanoparticles used in this study may have the potential to cause an inflammatory reaction, affecting the haemostatic physiology.
Description: Copyright: This is an Open Access journal. This journal authorizes the publication of the information herewith contained. Published in the International Journal of Morphology, Vol. 28 (4), pp 1263-1271
URI: http://www.scielo.cl/pdf/ijmorphol/v28n4/art44.pdf
http://hdl.handle.net/10204/6354
ISSN: 0717-9502
Appears in Collections:General science, engineering & technology

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