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Please use this identifier to cite or link to this item: http://hdl.handle.net/10204/5752

Title: Host gene targets for novel influenza therapies elucidated by high-throughput RNA interference screens
Authors: Meliopoulos, VA
Andersen, LE
Birrer, KF
Simpson, KJ
Lowenthal, JW
Bean, AGD
Stambas, J
Stewart, CR
Tompkins, SM
Van Beusechem, VW
Fraser, I
Mhlanga, M
Barichievy, S
Smith, Q
Leake, D
Karpilow, J
Buck, A
Jona, G
Tripp, RA
Keywords: Genome
Genome-wide RNA interference
Host gene targets
Influenza therapies
Issue Date: Jan-2012
Publisher: FASEB
Citation: Meliopoulos, VA, Andersen, LE, Birrer, KF, Simpson, KJ, Lowenthal, JW, Bean, AGD, Stambas, J, Stewart, CR, Tompkins, SM, Van Beusechem, VW, Fraser, I, Mhlanga, M, Barichievy, S, Smith, Q, Leake, D, Karpilow, J, Buck, A, Jona, G and Tripp, RA. 2012. Host gene targets for novel influenza therapies elucidated by high-throughput RNA interference screens. The FASEB Journal, doi: 10.1096/fj.11-193466
Series/Report no.: Workflow;8564
Abstract: Influenza virus encodes only 11 viral proteins but replicates in a broad range of avian and mammalian species by exploiting host cell functions. Genome-wide RNA interference (RNAi) has proven to be a powerful tool for identifying the host molecules that participate in each step of virus replication. Meta-analysis of findings from genome-wide RNAi screens has shown influenza virus to be dependent on functional nodes in host cell pathways, requiring a wide variety of molecules and cellular proteins for replication. Because rapid evolution of the influenza A viruses persistently complicates the effectiveness of vaccines and therapeutics, a further understanding of the complex host cell pathways coopted by influenza virus for replication may provide new targets and strategies for antiviral therapy. RNAi genome screening technologies together with bioinformatics can provide the ability to rapidly identify specific host factors involved in resistance and susceptibility to influenza virus, allowing for novel disease intervention strategies.
Description: Copyright: 2012 FASEB. This is an ABSTRACT ONLY. The definitive version is published in The FASEB Journal, doi: 10.1096/fj.11-193466
URI: http://www.fasebj.org/content/early/2012/01/09/fj.11-193466.full.pdf+html
ISSN: 0892-6638
Appears in Collections:Human factors
General science, engineering & technology

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