Access to a series of truncated ATP analogs, as potential anti-tuberculosis agents, has been explored via alkylation and acylation of 3-aminophenol, whereas chloroacetylation, using chloroacetyl chloride, and subsequent Arbuzov phosphonation of a series of 3-substituted anilines have afforded a series of phosphonate derivatives as potential antimalarial agents.
Reference:
Mutorwa, M, Salisu, S, Blatch, GL et al. 2009. 3-substituted anilines as scaffolds for the construction of glutamine synthetase and DXP-reductoisomerase inhibitors. Synthetic Communications, 39(15), pp 2723 - 2736
Mutorwa, M., Salisu, S., Blatch, G., Kenyon, C., & Kaye, P. (2009). 3-substituted anilines as scaffolds for the construction of glutamine synthetase and DXP-reductoisomerase inhibitors. http://hdl.handle.net/10204/5353
Mutorwa, M, S Salisu, GL Blatch, C Kenyon, and PT Kaye "3-substituted anilines as scaffolds for the construction of glutamine synthetase and DXP-reductoisomerase inhibitors." (2009) http://hdl.handle.net/10204/5353
Mutorwa M, Salisu S, Blatch G, Kenyon C, Kaye P. 3-substituted anilines as scaffolds for the construction of glutamine synthetase and DXP-reductoisomerase inhibitors. 2009; http://hdl.handle.net/10204/5353.
ResearchSpace
