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Please use this identifier to cite or link to this item: http://hdl.handle.net/10204/5353

Title: 3-substituted anilines as scaffolds for the construction of glutamine synthetase and DXP-reductoisomerase inhibitors
Authors: Mutorwa, M
Salisu, S
Blatch, GL
Kenyon, C
Kaye, PT
Keywords: Aniline derivatives
DXP-reductoisomerase inhibitors
Glutamine synthetase
Phosphonates
Synthetic communications
Issue Date: Jan-2009
Publisher: Taylor & Francis
Citation: Mutorwa, M, Salisu, S, Blatch, GL et al. 2009. 3-substituted anilines as scaffolds for the construction of glutamine synthetase and DXP-reductoisomerase inhibitors. Synthetic Communications, 39(15), pp 2723 - 2736
Series/Report no.: Workflow request;3345
Abstract: Access to a series of truncated ATP analogs, as potential anti-tuberculosis agents, has been explored via alkylation and acylation of 3-aminophenol, whereas chloroacetylation, using chloroacetyl chloride, and subsequent Arbuzov phosphonation of a series of 3-substituted anilines have afforded a series of phosphonate derivatives as potential antimalarial agents.
Description: Copyright: 2009 Taylor & Francis. This is an ABSTRACT ONLY
URI: http://www.tandfonline.com/doi/abs/10.1080/00397910802663444#preview
http://hdl.handle.net/10204/5353
ISSN: 0039-7911
Appears in Collections:Structural biology
General science, engineering & technology
Discovery chemistry

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