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Please use this identifier to cite or link to this item: http://hdl.handle.net/10204/4194

Title: Mycotoxic nephropathy in Bulgarian pigs and chickens: complex aetiology and similarity to Balkan endemic nephropathy
Authors: Stoev, SD
Dutton, MF
Njobeh, PB
Mosonik, JS
Steenkamp, PA
Keywords: High-performance liquid chromatography
Mycology
Screening assays
Toxicology
Animal study
Fumonisins
Mycotoxins
Mycotoxins fungi
Mycotoxins ochratoxin A
Animal feed
Issue Date: 2009
Publisher: Taylor & Francis
Citation: Stoev, SD, Dutton, MF, Njobeh, PB. 2009. Mycotoxic nephropathy in Bulgarian pigs and chickens: complex aetiology and similarity to Balkan endemic nephropathy. Food Additives and Contaminants, Part A: Chemistry Analysis Control Exposure & Risk Assessment, Vol. 27(1), pp 72-88
Abstract: Spontaneous nephropathy in Bulgaria, which is observed frequently during meat inspection and which differs morphologically from the classical description of mycotoxic porcine/chicken nephropathy as made in Denmark, was found to have a multi-mycotoxic aetiology being mainly provoked by a combined effect of ochratoxin A, penicillic acid and fumonisin B1 in addition to a not-yet-known metabolite. Mean contamination levels of ochratoxin A were consecutively low (188.8 and 376.4 mgkg_1) in contrast to high contamination levels of fumonisin B1 (5564.1 and 3254.5 mgkg_1) and penicillic acid (838.6 and 904.9 mgkg_1) for 2006 and 2007, respectively. Some other mycotoxins with lower importance such as citrinin, penitrem A, etc., may also influence clinicopathological picture of this nephropathy. A heavy contamination with Gibberella fujikuroi var. moniliformis (Fusarium verticillioides) and Penicillium aurantiogriseum complex (mainly Penicillium polonicum) was observed in almost all examined feed samples coming from pig and chick farms with nephropathy problems from Bulgaria. In contrast, low contamination with Aspergillus ochraceus, Penicillium verrucosum and Penicillium citrinum was observed in the same feed samples and these species were isolated as very rare components of the mycobiota.
Description: Copyright: 2009 Taylor & Francis. This is the authors pre-print version. The definitive version is published in the Journal of Food Additives and Contaminants, Part A: Chemistry Analysis Control Exposure & Risk Assessment, Vol. 27(1), pp 72-88
URI: http://pdfserve.informaworld.com/929781_769431896_914865098.pdf
http://hdl.handle.net/10204/4194
ISSN: 1944-0049
Appears in Collections:Analytical science
General science, engineering & technology

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