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Please use this identifier to cite or link to this item: http://hdl.handle.net/10204/3593

Title: Modelled temperature-dependent excitability behaviour of a generalised human peripheral sensory nerve fibre
Authors: Smit, JE
Hanekom, T
Hanekom, JJ
Keywords: Computational nerve fibre model
Conduction velocity
Chronaxie
Refractory periods
Persistent sodium current
Human peripheral sensory nerve fibre
Biological cybernetics
Ranvier node model
Human behaviour
Issue Date: Sep-2009
Publisher: Springer Science and Business Media
Citation: Smit, JE, Hanekom, T and Hanekom, JJ. 2009. Modelled temperature-dependent excitability behaviour of a generalised human peripheral sensory nerve fibre. Biological Cybernetics, Vol. 101(2). pp 115-130
Abstract: The objective of this study was to determine if a recently developed human Ranvier node model, which is based on a modified version of the Hodgkin-Huxley model, could predict the excitability behaviour in human peripheral sensory nerve fibres with diameters ranging from 5.0 – 15.0 µm. The Ranvier node model was extended to include a persistent sodium current and was incorporated into a generalised single cable nerve fibre model. Parameter temperature dependence was included. All calculations were performed in Matlab. Sensory nerve fibre excitability behaviour characteristics predicted by the new nerve fibre model at different temperatures and fibre diameters compared well with measured data. Absolute refractory periods deviated from measured data, while relative refractory periods were similar to measured data. Conduction velocities showed both fibre diameter and temperature dependence and were underestimated in fibres thinner than 12.5 µm. Calculated strength-duration time constants ranged from 128.5 µs to 183.0 µs at 37°C over the studied nerve fibre diameter range, with chronaxie times about 30% shorter than strength-duration time constants. Chronaxie times exhibited temperature dependence, with values overestimated by a factor 5 at temperatures lower than body temperature. Possible explanations include the deviated absolute refractory period trend and inclusion of a nodal strangulation relationship.
Description: Copyright: 2009 Springer Science & Business Media. This is the author's version of the work. It is posted here by permission of Springer for your personal use. Not for redistribution. The definitive version was published in the journal, Biological Cybernetics, Vol. 101(2), pp 115-130
URI: http://hdl.handle.net/10204/3593
ISSN: 0340-1200
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