Evaluation of nano encapsulation techniques in different polymeric system for the delivery of anti-tuberculosis drugs (ATD)

Abstract

In this study, isoniazid, one of the most potent anti-TB drugs, was successfully encapsulated in poly (D, L- lactide-co-glycolide) (PLG) and in alginate-chitosan polymeric systems using a double-emulsion method and a cation-induced gelation method, respectively. The formulations from both systems were spray dried to obtain free-flowing powder. For the PLG system, an increase in the temperature of the inlet drying air resulted in decreased particle size, as well as increased absolute zeta potential (surface charge) and encapsulation efficiency, whereas the alginate-chitosan system showed a decrease in the particle size, absolute zeta potential and encapsulation efficiency. The PLG system gave superior results, compared with the alginate-chitosan system, in terms of size, shape, absolute zeta potential and encapsulation efficiency