DSpace
 

Researchspace >
General science, engineering & technology >
General science, engineering & technology >
General science, engineering & technology >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10204/2691

Title: Antimalarial sesquiterpene lactones from oncosiphon piluliferum
Authors: Pillay, P
Maharaj, V
Crouch, N
Smith, P
Lategan, C
Vleggaar, R
Keywords: Antimalarial
Oncosiphon piluliferum
South Africa
Sesquiterpene lactones
Spectroscopic techniques
Cytotoxicity
Issue Date: Feb-2006
Citation: Pillay, P, Maharaj, V, Crouch, N et al. 2006. Antimalarial sesquiterpene lactones from oncosiphon piluliferum. CSIR Research and Innovation Conference: 1st CSIR Biennial Conference, CSIR International Convention Centre Pretoria, 27-28 February 2006, pp1
Abstract: With the emergence and spread of drug- resistant parasites, there is a need for new chemically diverse, effective antimalarial drugs. A national multidisciplinary consortium was established to validate scientifically South African medicinal plants for the treatment of malaria. Through this consortium, an indigenous plant, Oncosiphon piluliferum, was identified as a potential source of new antimalarial drugs. Bio-assay-guided fractionation based on in vitro antiplasmodial activity led to the isolation of five sesquiterpene lactones. Spectroscopic techniques and selected derivatisations were applied to fully characterise the compounds. The five compounds and their derivatives were found to possess varying degrees of in vitro antiplasmodial activity against the D10 P. falciparum strain and to possess cytotoxicity against Chinese Hamster Ovarian (CHO) cells
Description: CSIR Research and Innovation Conference: 1st CSIR Biennial Conference, CSIR International Convention Centre Pretoria, 27-28 February 2006
URI: http://hdl.handle.net/10204/2691
Appears in Collections:CSIR Conference 2006
General science, engineering & technology

Files in This Item:

File Description SizeFormat
Pillay_P_2006.pdf2.54 MBAdobe PDFView/Open
View Statistics

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2010  Duraspace - Feedback