dc.contributor.author |
Pillay, P
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|
dc.contributor.author |
Maharaj, V
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|
dc.contributor.author |
Crouch, N
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|
dc.contributor.author |
Smith, P
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|
dc.contributor.author |
Lategan, C
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|
dc.contributor.author |
Vleggaar, R
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|
dc.date.accessioned |
2008-12-10T11:02:29Z |
|
dc.date.available |
2008-12-10T11:02:29Z |
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dc.date.issued |
2006-02 |
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dc.identifier.citation |
Pillay, P, Maharaj, V, Crouch, N et al. 2006. Antimalarial sesquiterpene lactones from oncosiphon piluliferum. CSIR Research and Innovation Conference: 1st CSIR Biennial Conference, CSIR International Convention Centre Pretoria, 27-28 February 2006, pp1 |
en |
dc.identifier.uri |
http://hdl.handle.net/10204/2691
|
|
dc.description |
CSIR Research and Innovation Conference: 1st CSIR Biennial Conference, CSIR International Convention Centre Pretoria, 27-28 February 2006 |
en |
dc.description.abstract |
With the emergence and spread of drug- resistant parasites, there is a need for new chemically diverse, effective antimalarial drugs. A national multidisciplinary consortium was established to validate scientifically South African medicinal plants for the treatment of malaria. Through this consortium, an indigenous plant, Oncosiphon piluliferum, was identified as a potential source of new antimalarial drugs. Bio-assay-guided fractionation based on in vitro antiplasmodial activity led to the isolation of five sesquiterpene lactones. Spectroscopic techniques and selected derivatisations were applied to fully characterise the compounds. The five compounds and their derivatives were found to possess varying degrees of in vitro antiplasmodial activity against the D10 P. falciparum strain and to possess cytotoxicity against Chinese Hamster Ovarian (CHO) cells |
en |
dc.language.iso |
en |
en |
dc.subject |
Antimalarial |
en |
dc.subject |
Oncosiphon piluliferum |
en |
dc.subject |
South Africa |
en |
dc.subject |
Sesquiterpene lactones |
en |
dc.subject |
Spectroscopic techniques |
en |
dc.subject |
Cytotoxicity |
en |
dc.title |
Antimalarial sesquiterpene lactones from oncosiphon piluliferum |
en |
dc.type |
Conference Presentation |
en |
dc.identifier.apacitation |
Pillay, P., Maharaj, V., Crouch, N., Smith, P., Lategan, C., & Vleggaar, R. (2006). Antimalarial sesquiterpene lactones from oncosiphon piluliferum. http://hdl.handle.net/10204/2691 |
en_ZA |
dc.identifier.chicagocitation |
Pillay, P, V Maharaj, N Crouch, P Smith, C Lategan, and R Vleggaar. "Antimalarial sesquiterpene lactones from oncosiphon piluliferum." (2006): http://hdl.handle.net/10204/2691 |
en_ZA |
dc.identifier.vancouvercitation |
Pillay P, Maharaj V, Crouch N, Smith P, Lategan C, Vleggaar R, Antimalarial sesquiterpene lactones from oncosiphon piluliferum; 2006. http://hdl.handle.net/10204/2691 . |
en_ZA |
dc.identifier.ris |
TY - Conference Presentation
AU - Pillay, P
AU - Maharaj, V
AU - Crouch, N
AU - Smith, P
AU - Lategan, C
AU - Vleggaar, R
AB - With the emergence and spread of drug- resistant parasites, there is a need for new chemically diverse, effective antimalarial drugs. A national multidisciplinary consortium was established to validate scientifically South African medicinal plants for the treatment of malaria. Through this consortium, an indigenous plant, Oncosiphon piluliferum, was identified as a potential source of new antimalarial drugs. Bio-assay-guided fractionation based on in vitro antiplasmodial activity led to the isolation of five sesquiterpene lactones. Spectroscopic techniques and selected derivatisations were applied to fully characterise the compounds. The five compounds and their derivatives were found to possess varying degrees of in vitro antiplasmodial activity against the D10 P. falciparum strain and to possess cytotoxicity against Chinese Hamster Ovarian (CHO) cells
DA - 2006-02
DB - ResearchSpace
DP - CSIR
KW - Antimalarial
KW - Oncosiphon piluliferum
KW - South Africa
KW - Sesquiterpene lactones
KW - Spectroscopic techniques
KW - Cytotoxicity
LK - https://researchspace.csir.co.za
PY - 2006
T1 - Antimalarial sesquiterpene lactones from oncosiphon piluliferum
TI - Antimalarial sesquiterpene lactones from oncosiphon piluliferum
UR - http://hdl.handle.net/10204/2691
ER -
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en_ZA |