A synthetic route to an anti-cancer drug, lapatinib, was devised to support the development of a sustainable manufacturing process in South Africa. Quantitative metrics were employed to evaluate the sustainability of the key steps of the reaction.
Reference:
Stark, R., Rye, D., Newton, O., Deadman, B., Miller, P., Panayides, J., Riley, D.L. & Helldardt, K. et al. 2022. Assessing a sustainable manufacturing route to lapatinib. Reaction Chemistry & Engineering, 7. http://hdl.handle.net/10204/12682
Stark, R., Rye, D., Newton, O., Deadman, B., Miller, P., Panayides, J., ... Hii, K. (2022). Assessing a sustainable manufacturing route to lapatinib. Reaction Chemistry & Engineering, 7, http://hdl.handle.net/10204/12682
Stark, RT, DR Rye, OJ Newton, BJ Deadman, PW Miller, Jenny-Lee Panayides, Darren L Riley, K Helldardt, and KK Hii "Assessing a sustainable manufacturing route to lapatinib." Reaction Chemistry & Engineering, 7 (2022) http://hdl.handle.net/10204/12682
Stark R, Rye D, Newton O, Deadman B, Miller P, Panayides J, et al. Assessing a sustainable manufacturing route to lapatinib. Reaction Chemistry & Engineering, 7. 2022; http://hdl.handle.net/10204/12682.
