dc.contributor.author |
Wang, S
|
|
dc.contributor.author |
Panayides, Jenny-Lee
|
|
dc.contributor.author |
Riley, D
|
|
dc.contributor.author |
Tighe, CJ
|
|
dc.contributor.author |
Hii, KK
|
|
dc.date.accessioned |
2022-03-29T11:15:36Z |
|
dc.date.available |
2022-03-29T11:15:36Z |
|
dc.date.issued |
2021-09 |
|
dc.identifier.citation |
Wang, S., Panayides, J., Riley, D., Tighe, C. & Hii, K. 2021. Rapid formation of 2-lithio-1-(triphenylmethyl)imidazole and substitution reactions in flow†. <i>Reaction Chemistry & Engineering, 6(11).</i> http://hdl.handle.net/10204/12359 |
en_ZA |
dc.identifier.issn |
2058-9883 |
|
dc.identifier.uri |
DOI: 10.1039/d1re00343g
|
|
dc.identifier.uri |
http://hdl.handle.net/10204/12359
|
|
dc.description.abstract |
The functionalisation of imidazoles is a necessary step in the formation of many active pharmaceutical intermediates. Herein, we report a flow chemistry approach for the rapid and efficient formation of 2-lithio-1-(triphenylmethyl)imidazole at ambient temperature and its reaction with a range of electrophiles, achieving modest to high yields (40–94%) in short reaction times (<1 min). The method is amenable to the scale-up of this highly reactive lithio-imidazole intermediate. |
en_US |
dc.format |
Abstract |
en_US |
dc.language.iso |
en |
en_US |
dc.relation.uri |
https://pubs.rsc.org/en/content/articlelanding/2021/re/d1re00343g |
en_US |
dc.source |
Reaction Chemistry & Engineering, 6(11) |
en_US |
dc.subject |
2-lithio-1-(triphenylmethyl)imidazole |
en_US |
dc.subject |
Rapid formation |
en_US |
dc.subject |
Pharmaceutical intermediates |
en_US |
dc.title |
Rapid formation of 2-lithio-1-(triphenylmethyl)imidazole and substitution reactions in flow† |
en_US |
dc.type |
Article |
en_US |
dc.description.pages |
2018-2023 |
en_US |
dc.description.note |
© The Royal Society of Chemistry 2021. Due to copyright restrictions, the attached PDF file only contains the abstract of the full text item. For access to the full text item, please consult the publisher's website: https://pubs.rsc.org/en/content/articlelanding/2021/re/d1re00343g |
en_US |
dc.description.cluster |
Chemicals |
en_US |
dc.description.impactarea |
Pharmaceutical Technologies |
en_US |
dc.identifier.apacitation |
Wang, S., Panayides, J., Riley, D., Tighe, C., & Hii, K. (2021). Rapid formation of 2-lithio-1-(triphenylmethyl)imidazole and substitution reactions in flow†. <i>Reaction Chemistry & Engineering, 6(11)</i>, http://hdl.handle.net/10204/12359 |
en_ZA |
dc.identifier.chicagocitation |
Wang, S, Jenny-Lee Panayides, D Riley, CJ Tighe, and KK Hii "Rapid formation of 2-lithio-1-(triphenylmethyl)imidazole and substitution reactions in flow†." <i>Reaction Chemistry & Engineering, 6(11)</i> (2021) http://hdl.handle.net/10204/12359 |
en_ZA |
dc.identifier.vancouvercitation |
Wang S, Panayides J, Riley D, Tighe C, Hii K. Rapid formation of 2-lithio-1-(triphenylmethyl)imidazole and substitution reactions in flow†. Reaction Chemistry & Engineering, 6(11). 2021; http://hdl.handle.net/10204/12359. |
en_ZA |
dc.identifier.ris |
TY - Article
AU - Wang, S
AU - Panayides, Jenny-Lee
AU - Riley, D
AU - Tighe, CJ
AU - Hii, KK
AB - The functionalisation of imidazoles is a necessary step in the formation of many active pharmaceutical intermediates. Herein, we report a flow chemistry approach for the rapid and efficient formation of 2-lithio-1-(triphenylmethyl)imidazole at ambient temperature and its reaction with a range of electrophiles, achieving modest to high yields (40–94%) in short reaction times (<1 min). The method is amenable to the scale-up of this highly reactive lithio-imidazole intermediate.
DA - 2021-09
DB - ResearchSpace
DP - CSIR
J1 - Reaction Chemistry & Engineering, 6(11)
KW - 2-lithio-1-(triphenylmethyl)imidazole
KW - Rapid formation
KW - Pharmaceutical intermediates
LK - https://researchspace.csir.co.za
PY - 2021
SM - 2058-9883
T1 - Rapid formation of 2-lithio-1-(triphenylmethyl)imidazole and substitution reactions in flow†
TI - Rapid formation of 2-lithio-1-(triphenylmethyl)imidazole and substitution reactions in flow†
UR - http://hdl.handle.net/10204/12359
ER -
|
en_ZA |
dc.identifier.worklist |
25437 |
en_US |