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Hepatitis B core-based virus-like particles: A platform for vaccine development in plants

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dc.contributor.author Vahdat, MM
dc.contributor.author Hemmati, F
dc.contributor.author Ghorbani, A
dc.contributor.author Rutkowska, Daria A
dc.contributor.author Afsharifar, A
dc.contributor.author Eskandari, MH
dc.contributor.author Rezaei, N
dc.contributor.author Niazi, A
dc.date.accessioned 2022-02-27T16:43:54Z
dc.date.available 2022-02-27T16:43:54Z
dc.date.issued 2021-03
dc.identifier.citation Vahdat, M., Hemmati, F., Ghorbani, A., Rutkowska, D., Afsharifar, A., Eskandari, M., Rezaei, N. & Niazi, A. et al. 2021. Hepatitis B core-based virus-like particles: A platform for vaccine development in plants. <i>Biotechnology Reports, 29.</i> http://hdl.handle.net/10204/12297 en_ZA
dc.identifier.issn 2215-017X
dc.identifier.uri https://doi.org/10.1016/j.btre.2021.e00605
dc.identifier.uri http://hdl.handle.net/10204/12297
dc.description.abstract Virus-like particles (VLPs) are a class of structures formed by the self-assembly of viral capsid protein subunits and contain no infective viral genetic material. The Hepatitis B core (HBc) antigen is capable of assembling into VLPs that can elicit strong immune responses and has been licensed as a commercial vaccine against Hepatitis B. The HBc VLPs have also been employed as a platform for the presentation of foreign epitopes to the immune system and have been used to develop vaccines against, for example, influenza A and Foot-and-mouth disease. Plant expression systems are rapid, scalable and safe, and are capable of providing correct post-translational modifications and reducing upstream production costs. The production of HBc-based virus-like particles in plants would thus greatly increase the efficiency of vaccine production. This review investigates the application of plant-based HBc VLP as a platform for vaccine production. en_US
dc.format Abstract en_US
dc.language.iso en en_US
dc.relation.uri https://www.sciencedirect.com/science/article/pii/S2215017X21000217 en_US
dc.source Biotechnology Reports, 29 en_US
dc.subject Hepatitis B core en_US
dc.subject Plant expression system en_US
dc.subject Virus-like particle en_US
dc.subject VLP-based vaccine en_US
dc.title Hepatitis B core-based virus-like particles: A platform for vaccine development in plants en_US
dc.type Article en_US
dc.description.pages 10pp en_US
dc.description.note © 2021 Published by Elsevier B.V. Due to copyright restrictions, the attached PDF file only contains the abstract of the full text item. For access to the full text item, please consult the publisher's website: https://www.sciencedirect.com/science/article/pii/S2215017X21000217 en_US
dc.description.cluster Next Generation Health en_US
dc.description.impactarea Vetnry Mol Diagnostics and Vac en_US
dc.identifier.apacitation Vahdat, M., Hemmati, F., Ghorbani, A., Rutkowska, D., Afsharifar, A., Eskandari, M., ... Niazi, A. (2021). Hepatitis B core-based virus-like particles: A platform for vaccine development in plants. <i>Biotechnology Reports, 29</i>, http://hdl.handle.net/10204/12297 en_ZA
dc.identifier.chicagocitation Vahdat, MM, F Hemmati, A Ghorbani, Daria Rutkowska, A Afsharifar, MH Eskandari, N Rezaei, and A Niazi "Hepatitis B core-based virus-like particles: A platform for vaccine development in plants." <i>Biotechnology Reports, 29</i> (2021) http://hdl.handle.net/10204/12297 en_ZA
dc.identifier.vancouvercitation Vahdat M, Hemmati F, Ghorbani A, Rutkowska D, Afsharifar A, Eskandari M, et al. Hepatitis B core-based virus-like particles: A platform for vaccine development in plants. Biotechnology Reports, 29. 2021; http://hdl.handle.net/10204/12297. en_ZA
dc.identifier.ris TY - Article AU - Vahdat, MM AU - Hemmati, F AU - Ghorbani, A AU - Rutkowska, Daria AU - Afsharifar, A AU - Eskandari, MH AU - Rezaei, N AU - Niazi, A AB - Virus-like particles (VLPs) are a class of structures formed by the self-assembly of viral capsid protein subunits and contain no infective viral genetic material. The Hepatitis B core (HBc) antigen is capable of assembling into VLPs that can elicit strong immune responses and has been licensed as a commercial vaccine against Hepatitis B. The HBc VLPs have also been employed as a platform for the presentation of foreign epitopes to the immune system and have been used to develop vaccines against, for example, influenza A and Foot-and-mouth disease. Plant expression systems are rapid, scalable and safe, and are capable of providing correct post-translational modifications and reducing upstream production costs. The production of HBc-based virus-like particles in plants would thus greatly increase the efficiency of vaccine production. This review investigates the application of plant-based HBc VLP as a platform for vaccine production. DA - 2021-03 DB - ResearchSpace DP - CSIR J1 - Biotechnology Reports, 29 KW - Hepatitis B core KW - Plant expression system KW - Virus-like particle KW - VLP-based vaccine LK - https://researchspace.csir.co.za PY - 2021 SM - 2215-017X T1 - Hepatitis B core-based virus-like particles: A platform for vaccine development in plants TI - Hepatitis B core-based virus-like particles: A platform for vaccine development in plants UR - http://hdl.handle.net/10204/12297 ER - en_ZA
dc.identifier.worklist 25044 en_US


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