Virus-like particles (VLPs) are a class of structures formed by the self-assembly of viral capsid protein subunits and contain no infective viral genetic material. The Hepatitis B core (HBc) antigen is capable of assembling into VLPs that can elicit strong immune responses and has been licensed as a commercial vaccine against Hepatitis B. The HBc VLPs have also been employed as a platform for the presentation of foreign epitopes to the immune system and have been used to develop vaccines against, for example, influenza A and Foot-and-mouth disease. Plant expression systems are rapid, scalable and safe, and are capable of providing correct post-translational modifications and reducing upstream production costs. The production of HBc-based virus-like particles in plants would thus greatly increase the efficiency of vaccine production. This review investigates the application of plant-based HBc VLP as a platform for vaccine production.
Reference:
Vahdat, M., Hemmati, F., Ghorbani, A., Rutkowska, D., Afsharifar, A., Eskandari, M., Rezaei, N. & Niazi, A. et al. 2021. Hepatitis B core-based virus-like particles: A platform for vaccine development in plants. Biotechnology Reports, 29. http://hdl.handle.net/10204/12297
Vahdat, M., Hemmati, F., Ghorbani, A., Rutkowska, D., Afsharifar, A., Eskandari, M., ... Niazi, A. (2021). Hepatitis B core-based virus-like particles: A platform for vaccine development in plants. Biotechnology Reports, 29, http://hdl.handle.net/10204/12297
Vahdat, MM, F Hemmati, A Ghorbani, Daria Rutkowska, A Afsharifar, MH Eskandari, N Rezaei, and A Niazi "Hepatitis B core-based virus-like particles: A platform for vaccine development in plants." Biotechnology Reports, 29 (2021) http://hdl.handle.net/10204/12297
Vahdat M, Hemmati F, Ghorbani A, Rutkowska D, Afsharifar A, Eskandari M, et al. Hepatitis B core-based virus-like particles: A platform for vaccine development in plants. Biotechnology Reports, 29. 2021; http://hdl.handle.net/10204/12297.