ResearchSpace
→
Research Publications/Outputs
→
Journal Articles
→
Browsing Journal Articles by Cluster

Browsing Journal Articles by Cluster "Next Generation Health"

Now showing items 21-38 of 38

Previous Page

Micro- and nanofluidics for high throughput drug screening

Author: Mathekga, BSP ; Nxumalo, Precious Z ; Thimiri Govindaraj, Deepak B Date: Jan 2022 In this book chapter, we elaborate on the state-of-the-art technology developments in high throughput screening, microfluidics and nanofluidics. This book chapter further elaborated on the application of microfluidics and nanofluidics for ... Read more
New transmission-selective antimalarial agents through hit-to-lead optimization of 2-([1,1'-Biphenyl]-4-carboxamido)benzoic acid derivatives

Author: Reader, J ; Opperman, DFL ; Van der Watt, ME ; Theron, Anjo ; Leshabane, M ; Da Rocha, S ; Turner, J ; Garrabrant, K ; Piña, I ; Mills, C Date: Sep 2022 Malaria elimination requires multipronged approaches, including the application of antimalarial drugs able to block human-to-mosquito transmission of malaria parasites. The transmissible gametocytes of Plasmodium falciparum seem to be highly ... Read more
Patents and technology transfer in CRISPR technology

Author: Grobler, Lichelle R ; Suleman, Essa ; Thimiri Govindaraj, Deepak B Date: Feb 2021 CRISPR technology has revolutionized biological research in the last decade and many academic institutions and companies have patented CRISPR systems and applications. Several patents have been filed for various applications of CRISPR in ... Read more
Patents, ethics, biosafety and regulation using CRISPR technology

Author: Nxumalo, Precious Z ; Takundwa, MM ; Thimiri Govindaraj, Deepak B Date: Feb 2021 In this review chapter, we provide full comprehensive analysis on the patent, ethics and biosafety regulation with respect to the application of CRISPR technology in mammalian systems. We focused on recent development in CRISPR technology and ... Read more
Plant-based production of highly potent anti-HIV antibodies with engineered posttranslational modifications

Author: Singh, Advaita Acarya ; Pooe, O ; Kwezi, Lusisizwe ; Lotter-Stark, T ; Stoychev, Stoyan H ; Alexandra, Kabamba B ; Gerber, Isak B ; Bhiman, JN ; Vorster, J ; Pauly, M ; Zeitlin, L ; Whaley, K ; Mach, L ; Steinkellner, H ; Morris, L ; Tsekoa, Tsepo L ; Chikwamba, Rachel K Date: Apr 2020 Broadly neutralising antibodies (bNAbs) against human immunodeficiency virus type 1 (HIV-1), such as CAP256-VRC26 are being developed for HIV prevention and treatment. These Abs carry a unique but crucial post-translational modification (PTM), ... Read more
Polyelectrolyte multifaceted magnetic microcapsules for magnetic drug targeting at rheumatoid arthritic joints

Author: Latha, S ; Palanisamy, S ; Chakrapani, P ; Harinia, R ; Babu, PS ; Thimiri Govindaraj, Deepak B Date: Mar 2021 Background: Drug delivery is a science that requires the development of tailored systems that can deliver defi nedquantities of a therapeutic payload at a specifi c target site, at a controlled release rate, with or without a specifi c ... Read more
Precision medicine using drug repurposing platform - the way forward in applying novel drug combinations for Ovarian Cancer treatment

Author: Batohi, Nikayla ; Dreyer, G ; Thimiri Govindaraj, Deepak B Date: Jan 2023 More than half of the women diagnosed with ovarian cancer ultimately succumb to death after 5 years of diagnosis. Standard platinum-based chemotherapy often results in patient relapse; thus, new therapeutic strategies are required. We aim to ... Read more
Preparation and in-vitro evaluation of pantoprazole sodium magnetic microspheres by emulsion solvent evaporation method

Author: Latha, S ; Selvamani, P ; Suganya, G ; Thimiri Govindaraj, Deepak B ; Pal, TK Date: Jun 2021 Magnetic microspheres incorporated with pantoprazole sodium—a proton pump inhibitor—were formulated by using two different polymers such as ethyl cellulose and Eudragit RS-100. The magnetic microspheres were prepared by emulsion solvent ... Read more
The production of Newcastle disease virus-like particles in Nicotiana benthamiana as potential vaccines

Author: Smith, Tanya ; O’Kennedy, Martha M ; Ross, CS ; Lewis, NS ; Abolnik, C Date: Feb 2023 Newcastle disease (ND) is a highly contagious viral respiratory and neurological disease that has a severe impact on poultry production worldwide. In the present study, an expression platform was established for the transient production in ... Read more
Protective immunity of plant-produced African horse sickness virus serotype 5 chimaeric virus-like particles (VLPs) and viral protein 2 (VP2) vaccines in IFNAR-/- mice

Author: O'Kennedy, Maretha M ; Coetzee, P ; Koekemoer, O ; Du Plessis, L ; Lourens, CW ; Kwezi, Lusisizwe ; Du Preez, Ilse ; Mamputha, Sipho ; Rutkowska, Daria A ; Lemmer, Yolandy Date: Aug 2022 Next generation vaccines have the capability to contribute to and revolutionise the veterinary vaccine industry. African horse sickness (AHS) is caused by an arbovirus infection and is characterised by respiratory distress and/or cardiovascular ... Read more
Proteomic analysis identifies dysregulated proteins and associated molecular pathways in a cohort of gallbladder cancer patients of African ancestry

Author: Baichan, P ; Naicker, Previn ; Augustine, TN ; Smith, M ; Candy, G ; Devar, J ; Nweke, EE Date: Mar 2023 Background Gallbladder cancer (GBC) is a lethal cancer with a poor prognosis. The lack of specifc and sensitive biomarkers results in delayed diagnosis with most patients presenting at late stages of the disease. Furthermore, there is little ... Read more
Protocol for high-throughput semi-automated label-free- or TMT-based phosphoproteome profiling

Author: Koenig, C ; Martinez-Val, A ; Naicker, Previn ; Stoychev, S ; Jordaan, J ; Olsen, JV Date: Sep 2023 Tandem mass tags data-dependent acquisition (TMT-DDA) as well as data-independent acquisition-based label-free quantification (LFQ-DIA) have become the leading workflows to achieve deep proteome and phosphoproteome profiles. We present a ... Read more
Recent advances in genetic tools for engineering probiotic lactic acid bacteria

Author: Mugwanda, Kanganwiro ; Hamese, Saltiel ; Van Zyl, Winschau F ; Prinsloo, E ; Du Plessis, M ; Dicks, L ; Thimiri Govindaraj, Deepak B Date: Jan 2023 Synthetic biology has grown exponentially in the last few years, with a variety of biological applications. One of the emerging applications of synthetic biology is to exploit the link between microorganisms, biologics, and human health. To ... Read more
Recent advances in genome annotation and synthetic biology for the development of microbial chassis

Author: Hamese, Saltiel ; Mugwanda, Kanganwiro ; Takundwa, Mutsa M ; Prinsloo, E ; Thimiri Govindaraj, Deepak B Date: Dec 2023 This article provides an overview of microbial host selection, synthetic biology, genome annotation, metabolic modeling, and computational methods for predicting gene essentiality for developing a microbial chassis. This article focuses on ... Read more
Synthesis and characterisation of quantum dots coupled to mycolic acids as a water-soluble fluorescent probe for potential lateral flow detection of antibodies and diagnosis of tuberculosis

Author: Kabwe, KP ; Nsibande, SA ; Lemmer, Yolandy ; Pilcher, LA ; Forbes, PBC Date: Nov 2021 This work explores the potential use of cadmium-based quantum dots (QDs) coupled to mycolic acids (MAs) as a fluorescent probe to detect anti-MA antibodies which are biomarkers for tuberculosis (TB). The use of free MAs as antigens for the ... Read more
Synthetic biology meets precision medicine: Drug repurposing for bloodcancer precision medicine

Author: Thimiri Govindaraj, Deepak B Date: Nov 2021 Optimizing Drug discovery and Translation is one of the key tracks in Global Challenges Annual meeting 2019 and is the critical factor in achieving UN Sustainable Development Goals 3 Good Health and Well Being. WHO reports Cancer is the second ... Read more
Transient proteolysis reduction of Nicotiana benthamiana-produced CAP256 broadly neutralizing antibodies using CRISPR/Cas9

Author: Singh, Advaita A ; Pillay, Priyen ; Naicker, Previn ; Alexandre, Kabamba B ; Malatji, Kanyane ; Mach, L ; Steinkellner, H ; Vorster, J ; Chikwamba, Rachel K ; Tsekoa, Tsepo L Date: Aug 2022 The hypersensitive response is elicited by Agrobacterium infiltration of Nicotiana benthamiana, including the induction and accumulation of pathogenesis-related proteins, such as proteases. This includes the induction of the expression of ... Read more
Treatment strategies for multiple myeloma treatment and the role of high-throughput screening for precision cancer therapy

Author: Malise, TTA ; Nweke, EE ; Takundwa, Mutsa M ; Fru, PF ; Thimiri Govindaraj, Deepak B Date: May 2023 In the past few years, development of approved drug candidates has improved the disease management of multiple myeloma (MM). However, due to drug resistance, some of the patients do not respond positively, while some of the patients acquire ... Read more

Now showing items 21-38 of 38

Previous Page

Browse

All of ResearchSpace
This Collection
- By Issue Date
- Authors
- Titles
- Subjects
- Publication Type
- Cluster
- Impact Area

Quick Links

Legislation and compliance

General Enquiries

Tel: + 27 12 841 2911
Email: callcentre@csir.co.za

Physical Address
Meiring Naudé Road
Brummeria
Pretoria
South Africa

Postal Address
PO Box 395
Pretoria 0001
South Africa

Social Connect

Copyright © CSIR 2017. All Rights Reserved

Resources on this site are free to download and reuse according to associated licensing provision. Please read the terms and conditions of usage of each resource.